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Influence of genetic polymorphisms in homocysteine and lipid metabolism systems on antidepressant drug response.
BMC Psychiatry ( IF 4.4 ) Pub Date : 2020-08-14 , DOI: 10.1186/s12888-020-02798-4
Baoyu Yuan 1 , Xiaoyan Sun 1 , Zhi Xu 2, 3 , Mengjia Pu 1 , Yonggui Yuan 2, 3 , Zhijun Zhang 1, 2
Affiliation  

Variation in genes implicated in homocysteine and lipid metabolism systems may influence antidepressant response for patients with major depressive disorder (MDD). This study aimed to investigate whether association of polymorphisms on the MTHFR, ApoE and ApoA4 genes with the treatment response in MDD subjects. A total of 281 Han Chinese MDD patients received a single antidepressant drug (SSRI or SNRI) for at least 6 weeks, among whom 275 were followed up for 8 weeks. Their response to 6 weeks’ treatment and remission to 8 weeks’ treatment with antidepressant drugs was determined by changes in the 17-item Hamilton Depression Rating Scale (HARS-17) score. Single SNP and haplotype associations with treatment response were analyzed by UNPHASED 3.0.13. Logistic regression analysis was used to explore the interactions between genotypes and gender or drug type on treatment outcome, only those SNPs that had interactional association with gender or drug type were subjected to further stratified analysis. In total group, the haplotype (C-A) in MTHFR (rsl801133 and rs1801131) and the ApoE rs405509 AA genotype were significantly associated with better efficacy of antidepressants; In gender subgroups, only haplotype (C-A) in MTHFR (rsl801133 and rs1801131) was significantly associated with better efficacy of antidepressants in male subgroup; In drug type subgroup, the haplotype (C-A) in MTHFR (rsl801133 and rs1801131) and haplotype (G-C) in ApoE (rs7412 and rs405509) were associated with better efficacy of antidepressants in SNRI treated subgroup; The ApoA4 rs5092 G allele and GG genotype were associated with worse efficacy of antidepressants in SNRI treated subgroup. Genetic polymorphisms in homocysteine and lipid metabolism systems are associated with antidepressant response, particularly for the interactions of the certain genetic with gender or drug type.

中文翻译:

同型半胱氨酸和脂质代谢系统中的遗传多态性对抗抑郁药物反应的影响。

与高半胱氨酸和脂质代谢系统有关的基因变异可能会影响重度抑郁症(MDD)患者的抗抑郁反应。这项研究旨在调查MTHFR,ApoE和ApoA4基因的多态性是否与MDD受试者的治疗反应相关。共有281名汉族MDD患者接受了至少6周的抗抑郁药(SSRI或SNRI)治疗,其中275名患者接受了8周的随访。他们对17项汉密尔顿抑郁评估量表(HARS-17)评分的变化决定了他们对6周治疗的反应以及对8周抗抑郁药物治疗的缓解。通过UNPHASED 3.0.13分析了单个SNP和单倍型与治疗反应的关联。Logistic回归分析用于探讨基因型与性别或药物类型之间在治疗结果上的相互作用,只有那些与性别或药物类型具有相互作用关联的SNP才进行进一步的分层分析。总的来说,MTHFR的单倍型(CA)(rs18013和rs1801131)和ApoE rs405509 AA基因型与抗抑郁药的更好疗效显着相关。在性别亚组中,只有MTHFR的单倍型(CA)与男性亚组中的抗抑郁药疗效显着相关(rs1801313和rs1801131)。在药物类型亚组中,MTHFR中的单倍型(CA1)(rs1801131和rs1801131)和ApoE中的单倍型(GC)(rs7412和rs405509)与抗抑郁药在SNRI治疗的亚组中的更好疗效相关。在SNRI处理的亚组中,ApoA4 rs5092 G等位基因和GG基因型与抗抑郁药的不良疗效相关。高半胱氨酸和脂质代谢系统中的遗传多态性与抗抑郁反应有关,特别是对于某些遗传与性别或药物类型的相互作用。
更新日期:2020-08-14
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