The essential scope of the coronavirus infectious disease 2019 (COVID-19) pandemic is focused on developing effective treatments and vaccines for acute SARS-CoV-2 infection. There is also a critical need to develop interventions to prevent the complications of COVID-19, which occur with an alarming frequency in older adults. Since severe pathologic effects of infection occur with increasing age, COVID-19 falls under the geroscience concept that all diseases in older adults have a common and major underlying cause of declining function and resilience. Geroscience posits that manipulation of aging will simultaneously delay the appearance or severity of major diseases because they share the same risk factor: aging and the multiple processes involved in aging. Drug combinations that target multiple aging processes and the cytokine networks associated with them would not necessarily limit SARS-CoV-2 infection rates but would prevent severe pathologic consequences of the disease in older adults by maintaining a more youthful-like resilience to infection-related complications. A drug cocktail aimed at controlling cytokine actions would complement current clinical treatments and vaccine effectiveness for COVID-19 and serve as a prototype for future age-related infectious disease pandemics wherein the elderly population is especially vulnerable.

中文翻译：

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预防 COVID-19 病理后果的老年学方法。

2019 年冠状病毒传染病 (COVID-19) 大流行的基本范围集中在开发针对急性 SARS-CoV-2 感染的有效治疗方法和疫苗。还迫切需要制定干预措施来预防 COVID-19 的并发症，这些并发症在老年人中的发生频率惊人。由于感染的严重病理影响随着年龄的增长而发生，因此 COVID-19 属于老年学概念，即老年人的所有疾病都有一个共同的、主要的潜在原因，即功能和恢复力下降。Geroscience 认为，操纵衰老会同时延缓主要疾病的出现或严重程度，因为它们具有相同的风险因素：衰老和衰老所涉及的多个过程。针对多种衰老过程和与之相关的细胞因子网络的药物组合不一定会限制 SARS-CoV-2 感染率，但可以通过保持对感染相关并发症的更年轻的适应力来预防该疾病对老年人造成的严重病理后果. 旨在控制细胞因子作用的药物鸡尾酒将补充当前针对 COVID-19 的临床治疗和疫苗有效性，并作为未来与年龄相关的传染病大流行的原型，其中老年人口特别脆弱。