Scaffold-based bone tissue engineering is the most relevant approach for critical-sized bone defects. It is based on the use of three-dimensional substrates to provide the appropriate biomechanical environment for bone regeneration. Despite some successful results previously reported, scaffolds were never designed for disease treatment applications. This article proposes a novel dual-functional scaffold for cancer applications, comprising both treatment and regeneration functions. These functions are achieved by combining a biocompatible and biodegradable polymer and graphene. Results indicate that high concentrations of graphene enhance the mechanical properties of the scaffolds, also increasing the inhibition on cancer cell viability and proliferation.

中文翻译：

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新型聚（ε-己内酯）/石墨烯支架用于骨癌治疗和骨再生

基于支架的骨组织工程是解决临界骨缺损最相关的方法。它基于使用三维基底为骨骼再生提供适当的生物力学环境。尽管先前报道了一些成功的结果，但支架从未被设计用于疾病治疗应用。本文提出了一种新的用于癌症应用的双功能支架，包括治疗和再生功能。这些功能是通过组合生物相容性和可生物降解的聚合物与石墨烯来实现的。结果表明，高浓度的石墨烯增强了支架的机械性能，还增加了对癌细胞活力和增殖的抑制作用。