Translational Psychiatry ( IF 6.8 ) Pub Date : 2020-08-14 , DOI: 10.1038/s41398-020-00976-2 Shrujna Patel 1 , Russell C Dale 2 , Destanie Rose 3 , Brianna Heath 4 , Christine W Nordahl 4 , Sally Rogers 4 , Adam J Guastella 1 , Paul Ashwood 3
Epidemiological and animal research shows that maternal immune activation increases the risk of autism spectrum disorders (ASD) in offspring. Emerging evidence suggests that maternal immune conditions may play a role in the phenotypic expression of neurodevelopmental difficulties in children with ASD and this may be moderated by offspring sex. This study aimed to investigate whether maternal immune conditions were associated with increased severity of adverse neurodevelopmental outcomes in children with ASD. Maternal immune conditions were examined as predictors of ASD severity, behavioural and emotional well-being, and cognitive functioning in a cohort of 363 children with ASD (n = 363; 252 males, 111 females; median age 3.07 [interquartile range 2.64–3.36 years]). We also explored whether these outcomes varied between male and female children. Results showed that maternal asthma was the most common immune condition reported in mothers of children with ASD. A history of maternal immune conditions (p = 0.009) was more common in male children with ASD, compared to female children. Maternal immune conditions were associated with increased behavioural and emotional problems in male and female children. By contrast, maternal immune conditions were not associated with decreased cognitive function. The findings demonstrate that MIA may influence the expression of symptoms in children with ASD and outcomes may vary between males and females.
中文翻译:
患有自闭症谱系障碍的男性的孕产妇免疫状况增加,并且与行为和情感相关,但与认知合并症无关。
流行病学和动物研究表明,母亲的免疫激活会增加后代自闭症谱系障碍(ASD)的风险。越来越多的证据表明,母亲的免疫状况可能在ASD患儿神经发育障碍的表型表达中起作用,这可能由后代性别减轻。这项研究旨在调查母亲的免疫状况是否与ASD儿童不良神经发育结局的严重程度增加有关。在363例ASD儿童中,检查了母亲的免疫状况作为ASD严重程度,行为和情绪健康以及认知功能的预测指标(n = 363; 男性252名,女性111名; 中位年龄3.07 [四分位间距2.64-3.36岁]。我们还探讨了这些结果是否在男女儿童之间有所不同。结果显示,母亲哮喘是ASD儿童母亲中最常见的免疫疾病。 与女性儿童相比,男性ASD患儿的母亲免疫状况史(p = 0.009)更为常见。产妇的免疫状况与男女儿童行为和情绪问题的增加有关。相反,产妇的免疫状况与认知功能下降无关。研究结果表明,MIA可能会影响ASD儿童的症状表达,男女结果可能有所不同。