Abstract Novel methyl piperazinyl-quinolinyl α-aminophosphonates (MPQ-APs) (4a–4t) were synthesized by a one-pot reaction under microwave conditions, in the presence of a new Pd-SrTiO3 catalyst. 4a–4t were prepared from the substrates methyl piperazinyl-quinolinyl carbaldehyde, selected aniline derivatives and diethyl phosphite. MPQ-APs were characterized by FT-IR, 1H-NMR, 13C-NMR, 2D-NMR, 31P-NMR and high-resolution mass spectroscopy. The catalyst was prepared by a sequential reaction of Sr (II) nitrate, citric acid and Ti (IV) butoxide followed by reflux in the presence of Pd (II) nitrate. Pd-SrTiO3 was characterized by FT-IR, P-XRD, SEM, BET, SEM-EDX and Raman spectroscopy techniques. The MPQ-APs were screened in vitro for antibacterial activity against four strains of bacteria and three yeast cultures. Compounds 4m and 4r showed good positive results for antimicrobial activity in ciprofloxacin and compounds 4m, 4r and 4f gave positive results for antioxidant activity. Graphical Abstract

中文翻译：

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Pd-SrTiO3催化剂微波辐射合成甲基哌嗪基-喹啉基α-氨基膦酸酯衍生物及其抗菌抗氧化活性

摘要 在新型 Pd-SrTiO3 催化剂存在下，在微波条件下，通过一锅法反应合成了新型甲基哌嗪基-喹啉基 α-氨基膦酸酯（MPQ-APs）（4a-4t）。4a-4t 由底物甲基哌嗪基-喹啉基甲醛、选定的苯胺衍生物和亚磷酸二乙酯制备。MPQ-APs 的特点是 FT-IR、1H-NMR、13C-NMR、2D-NMR、31P-NMR 和高分辨率质谱。该催化剂是通过硝酸 Sr (II)、柠檬酸和丁醇钛 (IV) 的顺序反应制备的，然后在硝酸钯 (II) 存在下回流。通过FT-IR、P-XRD、SEM、BET、SEM-EDX和拉曼光谱技术对Pd-SrTiO3进行了表征。体外筛选 MPQ-AP 对四种细菌菌株和三种酵母培养物的抗菌活性。化合物 4m 和 4r 对环丙沙星的抗菌活性显示出良好的阳性结果，化合物 4m、4r 和 4f 对抗氧化活性显示出阳性结果。图形概要