Dillapiole n-butyl ether is a substance derived from dillapiole, which exhibits potential insecticidal effects on Aedes aegypti, the principal vector of the Dengue fever, Zika, and Chikungunya viruses, as well as Aedes albopictus, a vector of Dengue fever. As these mosquitoes are resistant to synthetic insecticides, dillapiole n-butyl ether may represent a valuable, plant-based alternative for their control. Dillapiole n-butyl ether has insecticidal and genotoxic effects on A. aegypti and A. albopictus, as shown by the reduction in clutch size and egg viability, and increased mortality rates, as well as a high frequency of micronuclei and chromosomal aberrations. However, the potential cytotoxic and genotoxic effects of this substance in mammals are still unknown. In Balb/C mice, structural changes were detected in hepatic, renal, and cardiac tissues, which were directly proportional to the concentration of the dose applied, in both genders. The induction of genotoxic, mutagenic, and cytotoxic effects was also observed at the highest concentrations (150 and 328 mg/kg). Further research will be necessary to better characterize the potential genotoxicity of this substance at lower concentrations, for the evaluation of the potential health risks related to its presence in environmental features, such as drinking water.

Dillapiole正丁醚是一种源自地拉比尔的物质，对登革热的主要媒介埃及伊蚊，寨卡病毒和基孔肯雅病毒以及登革热的媒介白纹伊蚊具有潜在的杀虫作用。由于这些蚊子对合成杀虫剂具有抗性，因此，二萜基正丁醚可能代表着一种有价值的，基于植物的替代品来控制它们。Dillapiole正丁基醚对埃及伊蚊和白纹伊蚊具有杀虫和遗传毒性作用，如离合器尺寸和卵子存活率的降低以及死亡率的增加以及微核和染色体畸变的高频率所表明。然而，该物质在哺乳动物中的潜在细胞毒性和遗传毒性作用仍是未知的。在Balb / C小鼠中，两种性别的肝，肾和心脏组织均检测到结构变化，这些变化与所用剂量的浓度成正比。在最高浓度（150和328 mg / kg）下也观察到了遗传毒性，诱变和细胞毒性作用的诱导。为了更好地表征该物质在较低浓度下的潜在遗传毒性，有必要进行进一步的研究，以评估与其在环境特征（如饮用水）中的存在有关的潜在健康风险。