Inflammasome complex is regarded as a major molecular regulator that exerts a significant function in caspase-1 activation and consequently, the development of cytokines like interleukin-1β (IL-1β) and interleukin-18 (IL-18). The secretion of these cytokines may induce inflammation. The role of inflammasomes in the pathologic process of eye-related illnesses like glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy has been well studied over the past decade. However, the detailed pathogenic mechanism of inflammasomes in these retinal diseases is still unknown. Therefore, further investigation and understanding various aspects of inflammasome complexes as well as their pivotal roles in the immunopathology of human ocular illnesses are essential. The present review aims to describe the significant involvement of inflammasomes in the immunopathology of important inflammatory retinal illnesses, including glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy focusing on anti-inflammasome therapy as a promising approach in the treatment of inflammation-related eye diseases.

炎症小体复合物被认为是主要的分子调节剂，在caspase-1激活中起着重要的作用，因此在细胞因子如白介素1β（IL-1β）和白介素18（IL-18）的发育中发挥重要作用。这些细胞因子的分泌可能诱发炎症。在过去的十年中，炎症小体在与眼有关的疾病（如青光眼，与年龄有关的黄斑变性（AMD）和糖尿病性视网膜病）的病理过程中的作用已得到充分研究。然而，炎症体在这些视网膜疾病中的详细致病机理仍是未知的。因此，进一步研究和理解炎症小体复合物的各个方面及其在人类眼部疾病的免疫病理学中的关键作用至关重要。