ABSTRACT

Introduction

Emergence of antibiotic resistance in bacteria is a complicated issue, especially when treating infectious immunodeficiency related diseases. In recent years, when compared to bulk materials, nanomaterials (NMs) with specific antibacterial activities have played a novel role in treating bacterial infections. Among NMs, quantum dots (QDs), specifically carbon containing QDs including graphene oxide QD (GOQD), graphene QD (GQD), and carbon QD (CQD), have demonstrated bacteriostatic and bactericidal activities via photodynamic (PD) effects against antibiotic resistant bacteria under a certain wavelength of light.

Area covered

In this mini-review, recent advances and challenges related to antibacterial and biocompatibility activities of modified GQD, GOQD, CQD, and carbon nanotubes (CNTs) are discussed.

Expert opinion

Lower stability and biocompatibility of QDs at higher doses in physiological conditions are major disadvantages. In this regard, functionalization of these QDs can result in appropriate bactericidal, biocompatibility, and biodegradability properties. In the case of CNTs including single-wall carbon nanotube (SWCNTs) and multiwall carbon nanotube (MWCNTs), aspect ratio (AR) is a determinant factor for the antibacterial value. Moreover, MWCNTs show a lower antibacterial ability compared to SWCNTs, which can be improved by modifying their surface.

中文翻译：

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功能化碳基纳米材料和具有抗菌活性的量子点：综述。

摘要

介绍

细菌中抗生素耐药性的出现是一个复杂的问题，尤其是在治疗感染性免疫缺陷相关疾病时。近年来，与散装材料相比，具有特定抗菌活性的纳米材料 (NMs) 在治疗细菌感染方面发挥了新的作用。在 NMs 中，量子点 (QD)，特别是含碳量子点，包括氧化石墨烯 QD (GOQD)、石墨烯 QD (GQD) 和碳 QD (CQD)，已通过光动力 (PD) 效应对抗生素耐药细菌表现出抑菌和杀菌活性在一定波长的光下。

覆盖面积

在这篇小型综述中，讨论了与改性 GQD、GOQD、CQD 和碳纳米管 (CNT) 的抗菌和生物相容性活动相关的最新进展和挑战。

专家意见

在生理条件下，较高剂量下量子点的稳定性和生物相容性较低是主要缺点。在这方面，这些量子点的功能化可以产生适当的杀菌、生物相容性和生物降解性。在碳纳米管包括单壁碳纳米管 (SWCNT) 和多壁碳纳米管 (MWCNT) 的情况下，纵横比 (AR) 是抗菌值的决定因素。此外，与单壁碳纳米管相比，多壁碳纳米管显示出较低的抗菌能力，这可以通过对其表面进行改性来改善。