Abstract Despite its insufficient availability, Copper-67 is currently attracting much attention for its enormous potential for cancer therapy as theranostic radionuclide. This work aims to accurately measure the unexplored cross section 70Zn(p,x)67Cu in the energy range 45–70 MeV and to evaluate its potential advantages in the case of high-intensity proton beams provided by compact cyclotrons. Thin target foils of enriched 70Zn were manufactured by lamination at the INFN-LNL and irradiated at the ARRONAX facility using the stacked-foils method. A radiochemical procedure for the separation of Cu, Ga and Zn contaminants and the isolation of 67Cu from the irradiated material was developed. The efficiency of the chemical processing was determined for each foil by monitoring the activity of selected tracer radionuclides (61Cu, 66Ga and 69mZn) through γ-spectrometry. Experimental data of the 70Zn(p,x)67Cu, 64Cu, 67Ga, 66Ga, 69mZn, 65Zn cross sections were measured for the first time in the energy range 45–70 MeV and compared with the theoretical results obtained by using the TALYS code. The 67Cu production yield by using enriched 70Zn thick targets was compared with the results obtained by using 68Zn targets in the same irradiation conditions.

中文翻译：

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通过富集的 70Zn 靶生产 67Cu：在 70Zn 与高于 45 MeV 的质子相互作用中对 67Cu、64Cu、67Ga、66Ga、69mZn 和 65Zn 的形成截面的首次测量

摘要 尽管铜 67 的可用性不足，但目前因其作为治疗诊断放射性核素在癌症治疗方面的巨大潜力而​​备受关注。这项工作旨在准确测量 45-70 MeV 能量范围内未探索的横截面 70Zn(p,x)67Cu，并评估其在紧凑型回旋加速器提供的高强度质子束情况下的潜在优势。富含 70Zn 的薄靶箔是通过在 INFN-LNL 层压制造的，并在 ARRONAX 设施中使用堆叠箔法进行辐照。开发了一种用于分离 Cu、Ga 和 Zn 污染物以及从辐照材料中分离 67Cu 的放射化学程序。通过监测选定示踪放射性核素（61Cu、66Ga 和 69mZn）通过 γ 光谱法。首次在 45-70 MeV 能量范围内测量了 70Zn(p,x)67Cu、64Cu、67Ga、66Ga、69mZn、65Zn 截面的实验数据，并与使用 TALYS 代码获得的理论结果进行了比较。将使用富集的 70Zn 厚靶材与使用 68Zn 靶材在相同辐照条件下获得的结果进行比较。