Abstract

The carbon–carbon double bond formation via neodymium-mediated Barbier-type reaction of ketones and allyl halides in the presence of diethyl phosphite is reported for the first time. The reaction is highly α-regioselective and was conveniently carried out under mild conditions in a one-pot fashion. From a synthetic point of view, a series of conjugated alkenes were obtained in moderate to good yields in this one-pot reaction with feasible reaction conditions.

中文翻译：

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在亚磷酸二乙酯存在下钕促进的烯丙基卤化物与酮的高选择性碳-碳双键形成

摘要

首次报道了在亚磷酸二乙酯存在下，通过钕介导的酮和烯丙基卤化物的Barbier型反应形成碳-碳双键。该反应是高度α-区域选择性的，并且在温和条件下以一锅法方便地进行。从合成的观点来看，在可行的反应条件下，在该一锅法反应中，以中等至良好的产率获得了一系列共轭烯烃。