The spliceostatins/thailanstatins are a family of linear peptides/polyketides that inhibit pre-mRNA splicing, and as such act as potent cytotoxic compounds. These compounds generally contain 9 stereocenters spread over a common (2Z,4S)-4-acetoxy-2-butenamide fragment, an (all-cis)-2,3,5,6-tetrasubstituted tetrahydropyran fragment and a terminal oxane ring joined by a dienyl chain. Due to the impressive antitumor properties of these compounds, along with their complex structure, a number of total syntheses have been reported. This review will compare the synthetic strategies reported through the end of 2019.

中文翻译：

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剪接他汀和泰兰他汀的合成：综述。

剪接他汀/泰兰他汀是一类线性肽/聚酮化合物，可抑制前 mRNA 剪接，因此可作为有效的细胞毒性化合物。这些化合物通常包含 9 个立体中心，分布在一个共同的 (2 Z ,4 S )-4-乙酰氧基-2-丁烯酰胺片段、一个（全顺式） -2,3,5,6-四取代的四氢吡喃片段和一个末端氧杂环己烷环上。由二烯基链连接。由于这些化合物令人印象深刻的抗肿瘤特性及其复杂的结构，已经报道了许多全合成。本次审查将比较截至 2019 年底报告的综合策略。