Five 2‐aroyl‐5‐bromobenzo[b]furan‐3‐ol compounds (two of which are new) and four new 2‐aroyl‐5‐iodobenzo[b]furan‐3‐ol compounds were synthesized starting from salicylic acid. The compounds were characterized by mass spectrometry and ¹H NMR and ¹³C NMR spectroscopy. Single‐crystal X‐ray diffraction studies of four compounds, namely, (5‐bromo‐3‐hydroxybenzofuran‐2‐yl)(4‐fluorophenyl)methanone, C₁₅H₈BrFO₃, (5‐bromo‐3‐hydroxybenzofuran‐2‐yl)(4‐chlorophenyl)methanone, C₁₅H₈BrClO₃, (5‐bromo‐3‐hydroxybenzofuran‐2‐yl)(4‐bromophenyl)methanone, C₁₅H₈Br₂O₃, and (4‐bromophenyl)(3‐hydroxy‐5‐iodobenzofuran‐2‐yl)methanone, C₁₅H₈BrIO₃, were also carried out. The compounds were tested for their in vitro cytotoxicity on the four human cancer cell lines KB, Hep‐G2, Lu‐1 and MCF7. Six compounds show good inhibiting abilities on Hep‐G2 cells, with IC₅₀ values of 1.39–8.03 µM.

中文翻译：

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一些2-芳酰基苯并呋喃-3-醇的合成，结构和体外细胞毒性测试。

从水杨酸开始合成了5种2芳酰基5溴苯并[ b ]呋喃3-醇化合物（其中2种是新化合物）和4种新的2芳酰基5碘苯并[ b ]呋喃3-醇化合物。通过质谱，¹ H NMR和¹³ C NMR光谱对化合物进行表征。四种化合物的单晶X射线衍射研究，即（5-溴-3-羟基苯并呋喃-2-基）（4-氟苯基）甲酮，C ₁₅ H ₈ BrFO ₃，（5-溴-3-羟基苯并呋喃2-基）（4-氯苯基）甲酮，C ₁₅ H ₈ BrClO ₃，（5-溴-3-基羟基苯并呋喃-2-基）（4-溴苯基）甲酮，C ₁₅ H ₈还进行了Br ₂ O ₃和（4-溴苯基）（3-羟基-5-碘苯并呋喃-2-基）甲酮C ₁₅ H ₈ BrIO _3的研究。测试了这些化合物对四种人类癌细胞系KB，Hep-G2，Lu-1和MCF7的体外细胞毒性。六种化合物对Hep‐G2细胞具有良好的抑制能力，IC ₅₀值为1.39–8.03 µM。