Traditional liquid marbles (LMs), liquid droplets encapsulated by hydrophobic particles at the liquid–gas interface, are restricted by their short lifetime and low heat transfer efficiency. Herein, a new paradigm for LMs immersed in various liquid mediums with massive enhanced heat transfer and spatial recognition is designed; without compromising the structural integrity, the lifetime of the liquid marbles in liquid (LMIL) is extended by ≈1000 times compared to classical LMs in air or naked droplets in organic reagents. The LMIL shows promising reverse structural re‐configurability while under external stimuli and maintaining their functionality for a very long period of time (≈weeks). These superior behaviors are further exploited as a miniature reactor with prolonged lifetimes and excellent temperature control, combined with its feasible operation, new opportunities will open up in the advanced chemical and biomedical engineering fields. It is also shown that LMIL can be applied in methylene blue degradation and 3D in‐vitro yeast cell cultures. These findings have important implications for real‐world use of LMs, with a number of applications in cell culture technology, lab‐in‐a‐drop, polymerization, encapsulation, formulation, and drug delivery.

中文翻译：

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液体中的液体弹珠。

传统的液体大理石（LMs），即在液气界面被疏水性颗粒包裹的液滴，由于使用寿命短和传热效率低而受到限制。本文设计了一种新的范式，用于浸没在各种液体介质中的LM，其传热和空间识别能力大大增强；在不损害结构完整性的前提下，与空气中的传统LM或有机试剂中的裸滴相比，液体中的大理石（LMIL）的使用寿命延长了约1000倍。LMIL在外部刺激下显示出有希望的反向结构可重新配置性，并且可以在很长一段时间（≈周）内保持其功能。这些优异的性能被进一步开发为具有延长寿命和出色温度控制的微型反应器，结合其可行的操作，将在先进的化学和生物医学工程领域开辟新的机遇。还显示LMIL可用于亚甲蓝降解和3D体外酵母细胞培养。这些发现对LM的实际应用具有重要意义，在细胞培养技术，滴滴实验室，聚合，封装，制剂和药物输送中有许多应用。