A novel antimicrobial dental self‐cured glass‐ionomer cement has been developed and evaluated. Alumina filler particles were covalently coated with an antibacterial polymer and blended into a self‐cured glass‐ionomer cement formulation. Surface hardness and bacterial viability were used to evaluate the modified cements. Results showed that the modified cements exhibited a significantly enhanced antibacterial activity along with improved surface hardness. Effects of antibacterial moiety content, alumina particle size and loading, and total filler content were investigated. It was found that increasing antibacterial moiety content, particle size and loading, and total filler content generally increased surface hardness. Increasing antibacterial moiety, filler loading and total filler content increased antibacterial activity. On the other hand, increasing particle size showed a negative impact on antibacterial activity. The leaching tests indicate no cytotoxicity produced from the modified cements to both bacteria and 3T3 mouse fibroblast cells.

中文翻译：

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具有改善抗菌功能和硬度的自固化玻璃离子水门汀

一种新型抗菌牙科自固化玻璃离子水门汀已被开发和评估。氧化铝填料颗粒共价涂覆有抗菌聚合物，并混合到自固化玻璃离子水门汀配方中。使用表面硬度和细菌活力来评估改性水泥。结果表明，改性水泥表现出显着增强的抗菌活性以及改善的表面硬度。研究了抗菌部分含量、氧化铝颗粒尺寸和负载量以及总填料含量的影响。研究发现，增加抗菌部分含量、粒径和负载量以及总填料含量通常会增加表面硬度。增加抗菌部分、填料负载和总填料含量会增加抗菌活性。另一方面，增加粒径对抗菌活性有负面影响。浸出测试表明改性水泥对细菌和 3T3 小鼠成纤维细胞没有产生细胞毒性。