The notoamides are a fascinating class of anticancer natural products where two phylogenetically related fungal strains have evolved to generate enantiomeric (mirror image) terminal products. A study of the enzymes (NotI/NotI′) responsible for spirocycle formation revealed their differential flexibility in accepting the opposite substrate and catalyzing formation of the respective spiro‐oxindole product. The preferential conversion of (−)‐stephacidin A by both enzymes suggests an evolutionary divergence from a common ancestor that was selective for (+)‐notoamide B/A production. More information can be found in the full paper by R. M. Williams, D. H. Sherman, et al.

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封面文章：黄素依赖性单加氧酶NotI和NotI'介导诺酰胺类生物合成中的螺-氧辛吲哚形成（ChemBioChem 17/2020）

Notoamides是一类引人入胜的抗癌天然产物，其中两个系统发育相关的真菌菌株已经进化出可产生对映体（镜像图像）的终端产物。对负责螺环形成的酶（NotI / NotI'）的研究表明，它们在接受相反的底物和催化各自螺-羟吲哚产物的形成中具有不同的柔韧性。两种酶对（-）-步石酸A的优先转化表明，它与对（+）-诺酰胺B / A生产具有选择性的共同祖先形成了进化分歧。R. M. Williams，D。H. Sherman等人的全文中提供了更多信息。