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Exosome: From leukemia progression to a novel therapeutic approach in leukemia treatment.
Biofactors ( IF 6 ) Pub Date : 2020-08-14 , DOI: 10.1002/biof.1669
Elham Gholipour 1, 2 , Parisa Sarvarian 1, 2 , Parisa Samadi 1, 2 , Mehdi Talebi 3 , Aliakbar Movassaghpour 3 , Roza Motavalli 4 , Mohammad Hojjat-Farsangi 5 , Mehdi Yousefi 2, 6, 7
Affiliation  

Exosomes, as small vesicles, are released by tumor cells and tumor microenvironment (cells and function as key intercellular mediators and effects on different processes including tumorigenesis, angiogenesis, drug resistance, and evasion from immune system. These functions are due to exosomes' biomolecules which make them as efficient markers in early diagnosis of the disease. Also, exosomes have been recently applied in vaccination. The potential role of exosomes in immune response toward leukemic cells makes them efficient immunotherapeutic agents treating leukemia. Furthermore, variations in exosomes contents make them beneficial to be used in treating different diseases. This review introduces the role of exosomes in the development of hematological malignancies and evaluates their functional role in the treatment of these malignancies.

中文翻译:

外泌体:从白血病进展到白血病治疗的新方法。

外泌体作为小囊泡由肿瘤细胞和肿瘤微环境(细胞和细胞作为关键的细胞间介质发挥作用,对肿瘤发生、血管生成、耐药性和免疫系统逃避等不同过程产生影响。这些功能是由于外泌体的生物分子使它们成为疾病早期诊断的有效标志物。此外,外泌体最近已应用于疫苗接种。外泌体在针对白血病细胞的免疫反应中的潜在作用使其成为治疗白血病的有效免疫治疗剂。此外,外泌体含量的变化使其有益本综述介绍了外泌体在血液系统恶性肿瘤发展中的作用,并评估了它们在治疗这些恶性肿瘤中的功能作用。
更新日期:2020-10-19
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