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Versatile Nickel(II) Scaffolds as Coordination-Induced Spin-State Switches for 19 F Magnetic Resonance-Based Detection.
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2020-08-13 , DOI: 10.1002/anie.202010587
Da Xie 1 , Meng Yu 1 , Zhu-Lin Xie 1 , Rahul T Kadakia 1 , Chris Chung 1 , Lauren E Ohman 1 , Kamyab Javanmardi 2 , Emily L Que 1
Affiliation  

19F magnetic resonance (MR) based detection coupled with well‐designed inorganic systems shows promise in biological investigations. Two proof‐of‐concept inorganic probes that exploit a novel mechanism for 19F MR sensing based on converting from low‐spin (S=0) to high‐spin (S=1) Ni2+ are reported. Activation of diamagnetic NiL1 and NiL2 by light or β‐galactosidase, respectively, converts them into paramagnetic NiL0, which displays a single 19F NMR peak shifted by >35 ppm with accelerated relaxation rates. This spin‐state switch is effective for sensing light or enzyme expression in live cells using 19F MR spectroscopy and imaging that differentiate signals based on chemical shift and relaxation times. This general inorganic scaffold has potential for developing agents that can sense analytes ranging from ions to enzymes, opening up diverse possibilities for 19F MR based biosensing.

中文翻译:

多功能镍(II)支架作为配位诱导的自旋状态开关,用于基于19 F磁共振的检测。

基于19 F磁共振(MR)的检测结合精心设计的无机系统在生物学研究中显示出了希望。报道了两种概念验证的无机探针,它们利用一种新的机制实现19 F MR传感,该机制基于从低自旋(S = 0)到高自旋(S = 1)Ni 2+的转换。光或β-半乳糖苷酶分别激活抗磁性NiL 1NiL 2,将它们转换为顺磁性NiL 0,显示单个19F NMR峰以加速的弛豫速率移动了> 35 ppm。这种自旋状态开关可使用19 F MR光谱学和成像技术,根据化学位移和弛豫时间区分信号,从而有效地检测活细胞中的光或酶表达。这种通用的无机支架具有开发试剂的潜力,该试剂可以检测从离子到酶的分析物,从而为基于19 F MR的生物传感打开了多种可能性。
更新日期:2020-08-13
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