Reciprocal interactions between tumor cells and immune cells shape the tumor microenvironment. Recent studies indicate that enhanced cell cycle activity in cancer cells suppresses antitumor immunity. Herein we discuss potential mechanisms by which cell cycle programs intrinsic to tumor cells are coupled to immune behavior, with consequences for immunotherapy.

中文翻译：

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细胞周期调节遇到肿瘤免疫抑制。

肿瘤细胞与免疫细胞之间的相互相互作用影响着肿瘤的微环境。最近的研究表明，癌细胞中增强的细胞周期活性抑制了抗肿瘤免疫力。在本文中，我们讨论了潜在机制，肿瘤细胞固有的细胞周期程序通过这些机制与免疫行为耦合，对免疫治疗产生影响。