Long noncoding RNAs (lncRNAs) are crucial regulators in diverse cellular contexts and biological processes. The subcellular localization of lncRNAs determines their modes of action. Compared to mRNAs, however, many mRNA-like lncRNAs are preferentially localized to the nucleus where they regulate chromatin organization, transcription, and different nuclear condensates. Recent studies have revealed the complex mechanisms that govern lncRNA nuclear retention. We review current understanding of how the transcription and processing of lncRNAs, motifs within lncRNAs, and trans-factors coordinately contribute to their nuclear retention in mammalian cells.

长的非编码RNA（lncRNA）在各种细胞环境和生物学过程中都是至关重要的调节剂。lncRNA的亚细胞定位决定了它们的作用方式。然而，与mRNA相比，许多类似mRNA的lncRNA优先位于细胞核中，在那里它们调节染色质的组织，转录和不同的核浓缩物。最近的研究已经揭示了控制lncRNA核保留的复杂机制。我们回顾了目前对lncRNA的转录和加工，lncRNA内的基序和反式因子如何协调地促进其在哺乳动物细胞中的核滞留的理解。