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Characterising the ocular surface and tear film in a population-based birth cohort of 45-year old New Zealand men and women.
The Ocular Surface ( IF 6.4 ) Pub Date : 2020-08-13 , DOI: 10.1016/j.jtos.2020.08.005
Jennifer P Craig 1 , Michael T M Wang 1 , Antony Ambler 2 , Kirsten Cheyne 2 , Graham A Wilson 3
Affiliation  

Purpose

To assess the prevalence of dry eye disease, aqueous tear deficiency, meibomian gland dysfunction, and asymptomatic ocular surface disease in a population-based cohort of 45-year-old New Zealand men and women.

Methods

This cross-sectional study of 885 participants (442 females, 443 males) was based on a population-representative birth cohort of individuals born between April 1 1972 and March 31 1973 in Dunedin, New Zealand (the Dunedin Multidisciplinary Health and Developmental Study). Participants were assessed at 45 years of age, and dry eye symptomology, ocular surface characteristics, and tear film quality were evaluated for each participant within a single clinical session. The diagnosis of dry eye disease was made according to the validated rapid non-invasive dry eye assessment algorithm.

Results

Clinical dry eye signs were present in 402 (45%) participants, of which 78 (9%) participants fulfilled the diagnostic criteria for dry eye disease, and 322 (37%) had asymptomatic ocular surface disease. Among participants with dry eye disease, 22 (2%) exhibited aqueous tear deficiency, and 65 (7%) had meibomian gland dysfunction. Females were more likely to be affected by dry eye disease, meibomian gland dysfunction, and asymptomatic ocular surface disease (all p < 0.05).

Conclusions

Clinical dry eye signs were present in almost half of this population-based cohort of 45-year-old New Zealanders, although only 9% of participants fulfilled the diagnostic criteria for dry eye disease. The high prevalence of asymptomatic ocular surface disease presents an opportunity for preventative public health intervention.



中文翻译:

在以人口为基础的45岁新西兰男女人群中,对眼表和泪膜进行表征。

目的

在45岁的新西兰男性和女性人群中评估干眼病,房水缺乏症,睑板腺功能障碍和无症状眼表疾病的患病率。

方法

这项针对885名参与者(442名女性,443名男性)的横断面研究基于1972年4月1日至1973年3月31日在新西兰达尼丁出生的人群的代表性出生队列(但尼丁多学科健康与发展研究)。在45岁时对参与者进行评估,并在单个临床会议中评估每个参与者的干眼症状,眼表特征和泪膜质量。根据经过验证的快速非侵入性干眼评估算法对干眼病进行诊断。

结果

402(45%)名受试者出现临床干眼症迹象,其中78名(9%)受试者符合干眼病的诊断标准,而322名(37%)有无症状的眼表疾病。在患有干眼病的参与者中,有22名(2%)表现出房水性泪液缺乏,而65名(7%)患有睑板腺功能障碍。女性更容易受到干眼病,睑板腺功能障碍和无症状眼表疾病的影响(所有p <0.05)。

结论

在这个以人口为基础的45岁新西兰人队列中,几乎有一半出现临床干眼症迹象,尽管只有9%的参与者符合干眼症的诊断标准。无症状眼表疾病的高流行为预防性公共卫生干预提供了机会。

更新日期:2020-08-13
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