Vapor-liquid distribution coefficients (K_D) of salicylic acid (SA) or methyl salicylate (MeS) in CO₂ - water - ethanol systems were measured under flow conditions of water/ethanol ratios of (1 to 4) mol/mol at (313 to 353) K and (10 to 20) MPa. The K_D of SA and MeS increased with pressure at constant temperature and with increasing water/ethanol ratios. Selectivity of SA versus MeS was highest (ca. 120) at water/ethanol feed ratios of 4 mol/mol, at 313 K and 20 MPa. Solute K_D values followed trends of the liquid phase ethanol activity coefficients. A three-constant empirical relationship was developed that uses the pure CO₂ reduced density and the feed ethanol mole fraction on a CO₂-free basis as parameters to reliably correlate K_D data and MeS/SA selectivities. The empirical relationship was also found to be applicable to flavonoid K_D data in CO₂ - water - ethanol systems.

在（1-4）mol / mol的水/乙醇比为（1-4）的流动条件下，测定了CO _2-水-乙醇体系中水杨酸（SA）或水杨酸甲酯（MeS）的汽液分布系数（K _D）。313至353）K和（10至20）MPa。在恒定温度下，SA和MeS的K _D随着压力的增加以及水/乙醇比的增加而增加。在313 K和20 MPa下，水/乙醇进料比为4 mol / mol时，SA对MeS的选择性最高（约120）。溶质K _D值遵循液相乙醇活度系数的趋势。建立了使用纯CO _2的三常数经验关系降低的密度和以无CO _2为基础的进料乙醇摩尔分数作为可靠地关联K _D数据和MeS / SA选择性的参数。还发现经验关系适用于CO _2-水-乙醇系统中的类黄酮K _D数据。