In the present study, Monte Carlo (MC) simulation and analytical calculation methods were used to investigate the potential of cancer treatment for the combination of IORT with nanoparticles (NPs). The Geant4 MC toolkit was used to simulate ZEISS INTRABEAM® IORT machine and its smallest applicator with 1.5 cm diameter. The dose enhancement effects (DEFs) were obtained for silver (Ag), gold (Au), bismuth (Bi), copper (Cu) and iron (Fe) spherical NPs considering different concentrations. In addition, analytical calculations were performed based on attenuation coefficient formula for sample NPs. Our MC results showed that the use of different NPs led to an increase in DEF up to 40%. Among different NPs, Au had the maximum DEF. In addition, analytical calculations revealed a significant increase, using NPs as well. Our study has suggested that the use of NPs in combination with IORT has the potential to enhance treatment outcomes.

在本研究中，蒙特卡罗 (MC) 模拟和分析计算方法用于研究 IORT 与纳米粒子 (NPs) 联合治疗癌症的潜力。Geant4 MC 工具包用于模拟蔡司 INTRABEAM® IORT 机器及其最小直径为 1.5 cm 的涂抹器。考虑到不同浓度，获得了银 (Ag)、金 (Au)、铋 (Bi)、铜 (Cu) 和铁 (Fe) 球形纳米粒子的剂量增强效应 (DEF)。此外，基于样品 NP 的衰减系数公式进行了分析计算。我们的 MC 结果表明，使用不同的 NP 导致 DEF 增加高达 40%。在不同的NPs中，Au的DEF最大。此外，分析计算显示显着增加，使用 NPs 也是如此。