Abstract Nanomaterials with enzyme-like catalytic activity, named as nanozymes, have aroused wide research interest owing to their striking merits bridging nanotechnology and biology. Metal-organic frameworks (MOFs) are a novel class of porous inorganic-organic hybrid materials made from metal ions/clusters and organic ligands, and have shown great prospect in the construction of novel nanozymes, making the as-emerged MOFs-based nanozymes promising candidates for biosensing, biocatalysis, biomedical imaging, and therapeutic applications. In this feature article, we tend to systematically summarize the recent process concerning MOFs-based nanozymes for combined cancer therapy, which emerged as a new trend in clinical oncology in view of the synergistic therapeutic efficacy and reduced side effects originating from different treatments. Firstly, classic kinds of MOFs-based nanozymes are briefly described with representatives for catalysis mechanism analysis. Secondly, general strategies for construction of MOFs-based nanozymes are discussed. Thirdly, recent advances in the application of MOFs-based nanozymes for dual or triple combination of therapeutic modalities have been reviewed in detail with a particular emphasis focusing upon underlying synergistic mechanisms involved in each combination formulation. Finally, current challenges and future perspectives of MOFs-based nanozymes with a view to maximizing their great potential in the research of translational medicine are also discussed. It is highly expected that our demonstration on this evolving area will play a more important role in the field of the personalized nanomedicine in combating cancer.

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用于联合癌症治疗的基于金属有机框架的纳米酶

摘要 具有类酶催化活性的纳米材料，被称为纳米酶，因其在纳米技术和生物学之间的显着优点而引起了广泛的研究兴趣。金属有机骨架（MOFs）是一类由金属离子/簇和有机配体制成的新型多孔无机有机杂化材料，在构建新型纳米酶方面显示出广阔的前景，使得新兴的基于MOFs的纳米酶具有广阔的应用前景。生物传感、生物催化、生物医学成像和治疗应用的候选者。在这篇专题文章中，我们倾向于系统地总结基于 MOFs 的纳米酶用于联合癌症治疗的最新进展，鉴于不同治疗产生的协同治疗效果和减少的副作用，它成为临床肿瘤学的新趋势。首先，简要描述了经典种类的基于 MOF 的纳米酶，并带有用于催化机理分析的代表。其次，讨论了构建基于 MOF 的纳米酶的一般策略。第三，详细回顾了基于 MOF 的纳米酶应用于双重或三重组合治疗方式的最新进展，特别强调了每种组合制剂中涉及的潜在协同机制。最后，还讨论了基于 MOF 的纳米酶的当前挑战和未来前景，以期最大限度地发挥其在转化医学研究中的巨大潜力。高度期待我们在这个不断发展的领域的演示将在个性化纳米医学领域对抗癌症中发挥更重要的作用。