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Аtherosclerosis-like changes in the rabbit aortic wall induced by immunization with native high-density lipoproteins.
Immunity, Inflammation and Disease ( IF 2.493 ) Pub Date : 2020-08-13 , DOI: 10.1002/iid3.339 Kseniya Fomina 1, 2 , Liubov Beduleva 1, 2 , Igor Menshikov 1, 2 , Abdulkadhim Zerjawi 1 , Alexey Terentiev 1, 2 , Alexandr Sidorov 1, 2 , Tatyana Khramova 1, 2 , Nadezhda Abisheva 1, 2 , Anna Gorbushina 1
Immunity, Inflammation and Disease ( IF 2.493 ) Pub Date : 2020-08-13 , DOI: 10.1002/iid3.339 Kseniya Fomina 1, 2 , Liubov Beduleva 1, 2 , Igor Menshikov 1, 2 , Abdulkadhim Zerjawi 1 , Alexey Terentiev 1, 2 , Alexandr Sidorov 1, 2 , Tatyana Khramova 1, 2 , Nadezhda Abisheva 1, 2 , Anna Gorbushina 1
Affiliation
A high level of total cholesterol or low‐density lipoprotein (LDL) cholesterol is considered the main cause of atherosclerosis and cardiovascular disease. For this reason, experimental atherosclerosis is induced by creating high blood cholesterol in animals. However, the hypothesis that atherosclerotic processes are mostly caused by immune (autoimmune) mechanisms has recently been gaining traction. At the same time, no experimental model has been developed that clearly demonstrates the autoimmune mechanism by which atherosclerosis develops and reproduces the full picture of atherosclerosis solely by means of an immune response, without resorting to additional interventions such as a high‐cholesterol diet or the use of genetic models of hyperlipidemia. Previously, we were able to induce atherosclerosis‐like lesions in the aorta and the development of pericardial fat in rats by immunizing them with human native lipoproteins. The purpose of this study was to test whether atherosclerosis can be induced in normocholesterolaemic rabbits by immunizing them with human native high‐density lipoproteins (hnHDL).
中文翻译:
用天然高密度脂蛋白免疫诱导兔主动脉壁的动脉粥样硬化样变化。
高水平的总胆固醇或低密度脂蛋白 (LDL) 胆固醇被认为是动脉粥样硬化和心血管疾病的主要原因。出于这个原因,实验性动脉粥样硬化是通过在动物体内产生高血胆固醇来诱导的。然而,动脉粥样硬化过程主要由免疫(自身免疫)机制引起的假设最近越来越受到关注。同时,还没有开发出实验模型可以清楚地证明动脉粥样硬化发展的自身免疫机制,并仅通过免疫反应再现动脉粥样硬化的全貌,而无需采取额外的干预措施,例如高胆固醇饮食或使用高脂血症的遗传模型。之前,通过用人类天然脂蛋白对大鼠进行免疫,我们能够在大鼠的主动脉中诱发动脉粥样硬化样病变和心包脂肪的形成。本研究的目的是测试是否可以通过用人天然高密度脂蛋白 (hnHDL) 免疫正常胆固醇血症兔来诱导动脉粥样硬化。
更新日期:2020-08-13
中文翻译:
用天然高密度脂蛋白免疫诱导兔主动脉壁的动脉粥样硬化样变化。
高水平的总胆固醇或低密度脂蛋白 (LDL) 胆固醇被认为是动脉粥样硬化和心血管疾病的主要原因。出于这个原因,实验性动脉粥样硬化是通过在动物体内产生高血胆固醇来诱导的。然而,动脉粥样硬化过程主要由免疫(自身免疫)机制引起的假设最近越来越受到关注。同时,还没有开发出实验模型可以清楚地证明动脉粥样硬化发展的自身免疫机制,并仅通过免疫反应再现动脉粥样硬化的全貌,而无需采取额外的干预措施,例如高胆固醇饮食或使用高脂血症的遗传模型。之前,通过用人类天然脂蛋白对大鼠进行免疫,我们能够在大鼠的主动脉中诱发动脉粥样硬化样病变和心包脂肪的形成。本研究的目的是测试是否可以通过用人天然高密度脂蛋白 (hnHDL) 免疫正常胆固醇血症兔来诱导动脉粥样硬化。