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Enantioselective Cascade Biocatalysis for Deracemization of Racemic β-Amino Alcohols to Enantiopure (S)-β-Amino Alcohols by Employing Cyclohexylamine Oxidase and ω-Transaminase.
ChemBioChem ( IF 3.2 ) Pub Date : 2020-08-12 , DOI: 10.1002/cbic.202000491
Jian-Dong Zhang 1 , Ya-Wen Chang 2 , Rui Dong 1 , Xiao-Xiao Yang 1 , Li-Li Gao 2 , Jing Li 1 , Shuang-Ping Huang 1 , Xing-Mei Guo 2 , Chao-Feng Zhang 1 , Hong-Hong Chang 1
Affiliation  

Coming to a resolution: Enantioselective cascade biocatalysis for deracemization of racemic β‐amino alcohols was conducted by employing cyclohexylamine oxidase and ω‐transaminase. (S)‐β‐amino alcohols were obtained in excellent conversions and ee values.
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中文翻译:

通过使用环己胺氧化酶和 ω-转氨酶将外消旋 β-氨基醇去外消旋化为对映体纯 (S)-β-氨基醇的对映选择性级联生物催化。

解决方案:通过使用环己胺氧化酶和ω-转氨酶进行对映选择性级联生物催化外消旋β-氨基醇的脱消旋。( S )-β-氨基醇以优异的转化率和ee值获得。
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更新日期:2020-08-12
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