Obesity is characterized by chronic inflammation of low grade. The cholinergic anti-inflammatory pathway favors the reduction of the inflammatory response. In this work the effect of stimulation of the cholinergic anti-inflammatory pathway on SHIRPA behavioral test and mitochondrial respiratory chain activity in obese mice was evaluated. The animals were paired in four groups: saline + control diet; donepezil + control diet; saline + high-fat diet and donepezil + high-fat diet. 5 mg/kg/day orally of donepezil or saline were given 7 days before the beginning of the diet until completing 11 weeks of the experiment. Food intake and body weight were measured. At the end of the experiment the animals were submitted to the SHIRPA behavioral test, soon after they were killed by decapitation, the open abdominal cavity and the mesenteric fat were removed. The hypothalamus, hippocampus, prefrontal cortex, and striatum were removed for evaluation of the mitochondrial respiratory chain. It can be observed that donepezil prevented weight gain and food consumption, as well as a tendency to prevent the accumulation of mesenteric fat in obese animals. There was no behavioral change in obese animals, nor did the influence of donepezil on these parameters. On the other hand, donepezil did not prevent inhibition of complex I activity, prevented the inhibition of complex II, and showed a tendency to prevent IV complex activity inhibited in obesity. With these results it can be concluded that the activation of the cholinergic anti-inflammatory pathway is promising for the alterations found in obesity.

肥胖的特征在于慢性低度炎症。胆碱能抗炎途径有助于减少炎症反应。在这项工作中，评估了胆碱能抗炎途径的刺激对肥胖小鼠SHIRPA行为测试和线粒体呼吸链活性的影响。将动物分为四组：盐水+对照饮食；和 多奈哌齐+控制饮食; 盐水+高脂饮食和多奈哌齐+高脂饮食。在开始饮食前7天口服5毫克/千克/天的多奈哌齐或生理盐水，直到完成实验的11周。测量食物摄入量和体重。实验结束时，动物被斩首处死，很快就接受了SHIRPA行为测试，将开放的腹腔和肠系膜脂肪去除。去除下丘脑，海马，前额叶皮层和纹状体，以评估线粒体呼吸链。可以观察到多奈哌齐可防止体重增加和食物消耗，以及防止肥胖动物中肠系膜脂肪积聚的趋势。肥胖动物没有行为改变，多奈哌齐对这些参数的影响也没有。另一方面，多奈哌齐不能防止复合物I活性的抑制，防止复合物II的抑制，并且显示出预防肥胖症中抑制IV复合物活性的趋势。从这些结果可以得出结论，胆碱能抗炎途径的激活对于肥胖中发现的改变是有希望的。去除纹状体和纹状体以评估线粒体呼吸链。可以观察到多奈哌齐可防止体重增加和食物消耗，以及防止肥胖动物中肠系膜脂肪积聚的趋势。肥胖动物没有行为改变，多奈哌齐对这些参数的影响也没有。另一方面，多奈哌齐不能防止复合物I活性的抑制，防止复合物II的抑制，并且显示出预防肥胖症中抑制IV复合物活性的趋势。从这些结果可以得出结论，胆碱能抗炎途径的激活对于肥胖中发现的改变是有希望的。去除纹状体和纹状体以评估线粒体呼吸链。可以观察到多奈哌齐可防止体重增加和食物消耗，以及防止肥胖动物中肠系膜脂肪积聚的趋势。肥胖动物没有行为改变，多奈哌齐对这些参数的影响也没有。另一方面，多奈哌齐不能防止复合物I活性的抑制，防止复合物II的抑制，并且显示出预防肥胖症中抑制IV复合物活性的趋势。从这些结果可以得出结论，胆碱能抗炎途径的激活对于肥胖中发现的改变是有希望的。以及防止肥胖动物中肠系膜脂肪积聚的趋势。肥胖动物没有行为改变，多奈哌齐对这些参数的影响也没有。另一方面，多奈哌齐不能防止复合物I活性的抑制，防止复合物II的抑制，并且显示出预防肥胖症中抑制IV复合物活性的趋势。从这些结果可以得出结论，胆碱能抗炎途径的激活对于肥胖中发现的改变是有希望的。以及防止肥胖动物中肠系膜脂肪积聚的趋势。肥胖动物没有行为改变，多奈哌齐对这些参数的影响也没有。另一方面，多奈哌齐不能防止复合物I活性的抑制，防止复合物II的抑制，并且显示出预防肥胖症中抑制IV复合物活性的趋势。从这些结果可以得出结论，胆碱能抗炎途径的激活对于肥胖中发现的改变是有希望的。