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Destruction of the stem cell Niche, Pathogenesis and Promising Treatment Targets for Primary Scarring Alopecias.
Stem Cell Reviews and Reports ( IF 4.8 ) Pub Date : 2020-08-12 , DOI: 10.1007/s12015-020-09985-6
Richard P Halley-Stott 1 , Henry A Adeola 2 , Nonhlanhla P Khumalo 2
Affiliation  

The Primary Scarring Alopecias are characterised by the irreversible destruction and fibrosis of hair follicles, leading to permanent and often disfiguring loss of hair. The pathophysiology of these diseases is not well understood. However, follicular-fibrosis and loss of the stem-cell niche appears to be a common theme. This review explores the pathogenesis of primary scarring alopecias, asking what happens to the stem cells of the hair follicle and how they may contribute to the progression of these diseases. Bulge-resident cells are lost (leading to loss of capacity for hair growth) from the follicle either by inflammatory-mediate apoptosis or through epigenetic reprogramming to assume a mesenchymal-like identity. What proportion of bulge cells is lost to which process is unknown and probably differs depending on the individual PCA and its specific inflammatory cell infiltrate. The formation of fibroblast-like cells from follicular stem cells may also mean that the cells of the bulge have a direct role in the pathogenesis. The identification of specific cells involved in the pathogenesis of these diseases could provide unique diagnostic and therapeutic opportunities to prevent disease progression by preventing EMT and specific pro-fibrotic signals.



中文翻译:

干细胞壁龛的破坏、原发性瘢痕性脱发的发病机制和有希望的治疗目标。

原发性瘢痕性脱发的特点是毛囊不可逆转的破坏和纤维化,导致永久性的、经常毁容的脱发。这些疾病的病理生理学尚不清楚。然而,毛囊纤维化和干细胞生态位的丧失似乎是一个共同的主题。这篇综述探讨了原发性瘢痕性脱发的发病机制,询问毛囊干细胞发生了什么变化,以及它们如何促进这些疾病的进展。通过炎症介导的细胞凋亡或通过表观遗传重编程以呈现间充质样特征,毛囊中的膨出常驻细胞丢失(导致毛发生长能力丧失)。哪个过程丢失了多少凸起细胞的比例是未知的,并且可能因个体 PCA 及其特定的炎症细胞浸润而异。由滤泡干细胞形成成纤维细胞样细胞也可能意味着凸起的细胞在发病机制中具有直接作用。鉴定参与这些疾病发病机制的特定细胞可以提供独特的诊断和治疗机会,通过防止 EMT 和特定的促纤维化信号来防止疾病进展。

更新日期:2020-08-14
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