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Acute changes of global and longitudinal right ventricular function: an exploratory analysis in patients undergoing open-chest mitral valve surgery, percutaneous mitral valve repair and off-pump coronary artery bypass grafting.
Cardiovascular Ultrasound ( IF 1.9 ) Pub Date : 2020-08-12 , DOI: 10.1186/s12947-020-00218-x
Marius Keller 1 , Tim Heller 1 , Tobias Lang 2 , Johannes Patzelt 3 , Juergen Schreieck 4 , Christian Schlensak 5 , Peter Rosenberger 1 , Harry Magunia 1
Affiliation  

Right ventricular (RV) function is an important prognostic indicator. The acute effects of cardiac interventions or cardiac surgery on global and longitudinal RV function are not entirely understood. In this study, acute changes of RV function during mitral valve surgery (MVS), percutaneous mitral valve repair (PMVR) and off-pump coronary artery bypass surgery (OPCAB) were investigated employing 3D echocardiography. Twenty patients scheduled for MVS, 23 patients scheduled for PMVR and 25 patients scheduled for OPCAB were included retrospectively if patients had received 3D transesophageal echocardiography before and immediately after MVS, PMVR or OPCAB, respectively. RV global and longitudinal function was assessed using a 3D multiparameter set consisting of global right ventricular ejection fraction (RVEF), tricuspid annular plane systolic excursion (TAPSE), longitudinal contribution to RVEF (RVEFlong) and free wall longitudinal strain (FWLS). Longitudinal RV function was significantly depressed immediately after MVS, as reflected by all parameters (RVEFlong: 20 ± 5% vs. 13 ± 6%, p < 0.001, TAPSE: 13.1 ± 5.1 mm vs. 11.0 ± 3.5 mm, p = 0.04 and FWLS: −20.1 ± 7.1% vs. -15.4 ± 5.1%, p < 0.001, respectively). The global RVEF was slightly impaired, but the difference did not reach significance (37 ± 13% vs. 32 ± 9%, p = 0.15). In the PMVR group, both global and longitudinal RV function parameters were unaltered, whereas the OPCAB group showed a slight reduction of RVEFlong only (18 ± 7% vs. 14 ± 5%, p < 0.01). RVEFlong yielded moderate case-to-case but good overall reproducibility. TAPSE, FWLS and RVEFlong reflect the depression of longitudinal compared to global RV function initially after MVS. PMVR alone had no impact, while OPCAB had a slight impact on longitudinal RV function. The prognostic implications of these phenomena remain unclear and require further investigation.

中文翻译:

整体和纵向右心室功能的急性变化:接受开胸二尖瓣手术、经皮二尖瓣修复和非体外循环冠状动脉旁路移植术患者的探索性分析。

右心室(RV)功能是重要的预后指标。心脏介入或心脏手术对全局和纵向 RV 功能的急性影响尚不完全清楚。在这项研究中,使用 3D 超声心动图研究了二尖瓣手术 (MVS)、经皮二尖瓣修复 (PMVR) 和非体外循环冠状动脉搭桥手术 (OPCAB) 期间 RV 功能的急性变化。如果患者分别在 MVS、PMVR 或 OPCAB 之前和之后立即接受了 3D 经食道超声心动图,则将 20 名计划接受 MVS 的患者、23 名计划接受 PMVR 的患者和 25 名计划接受 OPCAB 的患者纳入回顾性研究。使用由整体右心室射血分数 (RVEF)、三尖瓣环平面收缩偏移 (TAPSE)、对 RVEF 的纵向贡献 (RVEFlong) 和游离壁纵向应变 (FWLS)。纵向 RV 功能在 MVS 后立即显着降低,如所有参数所反映(RVEFlong:20 ± 5% 与 13 ± 6%,p < 0.001,TAPSE:13.1 ± 5.1 mm 与 11.0 ± 3.5 mm,p = 0.04 和FWLS:分别为 -20.1 ± 7.1% 与 -15.4 ± 5.1%,p < 0.001)。全球 RVEF 略有受损,但差异未达到显着性(37 ± 13% 对 32 ± 9%,p = 0.15)。在 PMVR 组中,全局和纵向 RV 功能参数均未改变,而 OPCAB 组仅显示 RVEFlong 略有减少(18 ± 7% 对 14 ± 5%,p < 0.01)。RVEFlong 产生中等的个案,但良好的整体重现性。TAPSE,FWLS 和 RVEFlong 反映了 MVS 后最初纵向与全局 RV 功能相比的降低。PMVR 本身没有影响,而 OPCAB 对纵向 RV 功能有轻微影响。这些现象的预后意义尚不清楚,需要进一步调查。
更新日期:2020-08-14
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