Abstract

Might COVID-19 vaccines sensitize humans to antibody-dependent enhanced (ADE) breakthrough infections? This is unlikely because coronavirus diseases in humans lack the clinical, epidemiological, biological, or pathological attributes of ADE disease exemplified by dengue viruses (DENV). In contrast to DENV, SARS and MERS CoVs predominantly infect respiratory epithelium, not macrophages. Severe disease centers on older persons with preexisting conditions and not infants or individuals with previous coronavirus infections. Live virus challenge of animals given SARS or MERS vaccines resulted in vaccine hypersensitivity reactions (VAH), similar to those in humans given inactivated measles or respiratory syncytial virus vaccines. Safe and effective COVID-19 vaccines must avoid VAH.

中文翻译：

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COVID 19疫苗：我们应该害怕ADE吗？

摘要

COVID-19疫苗可能会使人对抗体依赖性增强（ADE）突破性感染敏感吗？这是不可能的，因为人类的冠状病毒疾病缺乏登革热病毒（DENV）所代表的ADE疾病的临床，流行病学，生物学或病理学特征。与DENV相反，SARS和MERS CoV主要感染呼吸道上皮，而不是巨噬细胞。严重的疾病集中于已有疾病的老年人，而不是婴儿或以前患有冠状病毒感染的个体。接种SARS或MERS疫苗的动物对活病毒的攻击导致疫苗超敏反应（VAH），与使用灭活麻疹或呼吸道合胞病毒疫苗的人类相似。安全有效的COVID-19疫苗必须避免使用VAH。