Sulfoxide synthases are non-heme iron enzymes that catalyze oxidative carbonsulfur bond formation in the biosynthesis of thiohistidines such as ergothioneine and ovothiol. The catalytic mechanism of these enzymes has been studied by protein crystallography, steady-state kinetics, non-natural amino acid incorporation and computational modeling. This review discusses the current status of this research and also highlights similarities between the CS bond forming activity of sulfoxide synthases with that of synthetic coordination compounds.

中文翻译：

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亚砜合成酶的催化机制。

亚砜合酶是非血红素铁酶，可在硫代组氨酸（如麦角硫因和卵硫醇）的生物合成中催化氧化碳硫键的形成。这些酶的催化机制已通过蛋白质晶体学、稳态动力学、非天然氨基酸掺入和计算模型进行了研究。本综述讨论了这项研究的现状，并强调了亚砜合酶的 CS 键形成活性与合成配位化合物的 CS 键形成活性之间的相似性。