The controlled modification of surface properties represents a pervasive requirement to be fulfilled when developing new technologies. In this paper, we propose an easy-to-implement protocol for the functionalization of glass with self-assembled monolayers (SAMs). The adaptivity of the synthesis route was demonstrated by the controlled anchoring of thiol, amino, glycidyloxy, and methacrylate groups onto the glass surface. The optimization of the synthetic pathway was mirrored by extremely smooth SAMs (approximately 150 pm roughness), layer thickness comparable to the theoretical molecule length, absence of silane islands along the surface, quasi-unitary degree of packing, and tailored wettability and charge. The functionalization kinetics of two model silanes, 3-mercapto- and 3-amino-propyltrimethoxysilane, was determined by cross-comparing x-ray photoelectron spectroscopy and time of flight secondary ion mass spectrometry data. Our SAMs with tailored physicochemical attributes will be implemented as supports for the crystallization of pharmaceuticals and biomolecules in upcoming studies. Here, the application to a small molecule drug model, namely aspirin, was discussed as a proof of concept.

中文翻译：

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高质量有机硅烷自组装单层的通用和自适应合成协议，作为用于生化应用的可调表面化学平台。

在开发新技术时，表面特性的受控改性代表了普遍需要满足的要求。在本文中，我们提出了一种易于实施的协议，用于具有自组装单层 (SAM) 的玻璃功能化。硫醇、氨基、缩水甘油氧基和甲基丙烯酸酯基团在玻璃表面的受控锚定证明了合成路线的适应性。合成途径的优化体现在极其光滑的 SAM（粗糙度约为 150 pm）、与理论分子长度相当的层厚度、沿表面没有硅烷岛、准统一的堆积程度以及定制的润湿性和电荷。两种模型硅烷的官能化动力学，3-巯基-和 3-氨基-丙基三甲氧基硅烷，通过交叉比较 X 射线光电子能谱和飞行时间二次离子质谱数据确定。我们具有定制物理化学属性的 SAM 将在即将进行的研究中作为药物和生物分子结晶的支持。在这里，讨论了对小分子药物模型（即阿司匹林）的应用作为概念证明。