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Antibiotic Loaded Nano Rod Bone Cement for the Treatment of Osteomyelitis
Recent Patents on Nanotechnology ( IF 2 ) Pub Date : 2021-02-28 , DOI: 10.2174/1872210514666200811103724
Mala Rajendran 1 , Gazana Iraivan 1 , Ghayathri B L 1 , Preetha Mohan 1 , Keerthana R Chandran 1 , Hari P Nagaiah 1 , Ruby C A Selvaraj 1
Affiliation  

Background: Polymethyl Methacrylate (PMMA) bone cement is the clinical gold standard biomaterial for local antibiotic therapy in osteomyelitis. However, it releases 50% of the antibiotic within the first three days. It generates excessive heat during polymerization and is non-biodegradable. It must be removed by another operation. The best-known alternative for PMMA is hydroxyapatite.

Objectives: The present patented work is focused on synthesizing the biodegradable hydroxyapatite in nano form for slow and sustained release of antibiotics and studying the release kinetics of antibiotics.


中文翻译:

抗生素负载纳米棒骨水泥用于治疗骨髓炎

背景:聚甲基丙烯酸甲酯(PMMA)骨水泥是骨髓炎局部抗生素治疗的临床金标准生物材料。但是,它会在前三天内释放 50% 的抗生素。它在聚合过程中会产生过多的热量并且不可生物降解。必须通过其他操作将其删除。PMMA 最著名的替代品是羟基磷灰石。

目的:本专利工作的重点是合成纳米形式的可生物降解羟基磷灰石,用于缓释和缓释抗生素,并研究抗生素的释放动力学。
更新日期:2021-05-04
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