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2'-Fluoro-2'-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705.
Archives of Virology ( IF 2.7 ) Pub Date : 2020-08-08 , DOI: 10.1007/s00705-020-04759-4
Peifa Yu 1 , Yining Wang 1 , Yunlong Li 1 , Yang Li 1 , Zhijiang Miao 1 , Maikel P Peppelenbosch 1 , Qiuwei Pan 1
Affiliation  

Noroviruses are the main causative agents of acute viral gastroenteritis worldwide. However, no vaccine or specific antiviral treatment is available, imposing a heavy global health burden. The nucleoside analogue 2'-fluoro-2'-deoxycytidine (2'-FdC) has been reported to have broad antiviral activity. Here, we report that 2'-FdC significantly inhibits murine norovirus replication in macrophages. This effect was partially reversed by exogenous supplementation of cytidine triphosphate. The combination of 2'-FdC with mycophenolic acid, ribavirin or favipiravir (T705) exerts synergistic antiviral effects. These results indicate that 2'-FdC is a potential candidate for antiviral drug development against norovirus infection.

中文翻译:

2'-氟-2'-脱氧胞苷抑制鼠诺如病毒的复制并协同MPA,利巴韦林和T705。

诺如病毒是全世界急性病毒性胃肠炎的主要病原体。但是,目前尚无疫苗或抗病毒治疗方法,对全球健康构成沉重负担。据报道,核苷类似物2'-氟-2'-脱氧胞苷(2'-FdC)具有广泛的抗病毒活性。在这里,我们报道2'-FdC显着抑制巨噬细胞中的鼠诺如病毒复制。外源补充胞苷三磷酸可部分逆转这种作用。2'-FdC与麦考酚酸,利巴韦林或favipiravir(T705)的组合具有协同抗病毒作用。这些结果表明2'-FdC是针对诺如病毒感染的抗病毒药物开发的潜在候选人。
更新日期:2020-08-08
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