Koala retrovirus (KoRV) is a major threat to koala health and conservation. It also represents a series of challenges across the fields of virology, immunology, and epidemiology that are of great potential interest to any researcher in the field of retroviral diseases. KoRV is a gammaretrovirus that is present in both endogenous and exogenous forms in koala populations, with a still-active endogenization process. KoRV may induce immunosuppression and neoplastic conditions such as lymphoma and leukemia and play a role in chlamydiosis and other diseases in koalas. KoRV transmission modes, pathogenesis, and host immune response still remain unclear, and a clear understanding of these areas is critical for devising effective preventative and therapeutic strategies. Research on KoRV is clearly critical for koala conservation. In this review, we provide an overview of the current understanding and future challenges related to KoRV epidemiology, transmission mode, pathogenesis, and host immune response and discuss prospects for therapeutic and preventive vaccines.

中文翻译：

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考拉逆转录病毒的流行病学，传播方式，发病机理和宿主免疫反应在考拉（Phascolarctos灰质）。

考拉逆转录病毒（KoRV）是对考拉健康和保护的主要威胁。它也代表了病毒学，免疫学和流行病学领域的一系列挑战，这对逆转录病毒疾病领域的任何研究者都具有巨大的潜在利益。KoRV是一种伽马逆转录病毒，在考拉种群中以内源性和外源性形式存在，并且内源性过程仍然活跃。KoRV可能诱发免疫抑制和肿瘤性疾病，例如淋巴瘤和白血病，并在考拉的衣原体病和其他疾病中起作用。尚不清楚KoRV的传播方式，发病机理和宿主免疫反应，因此对这些区域的清楚了解对于制定有效的预防和治疗策略至关重要。对KoRV的研究显然对保护考拉至关重要。在这篇评论中