MHI-148 is a type of heptamethine cyanine dye that can cross the cytoplasmic membrane of lung cancer cells. Here we tested the cytotoxic, in vivo imaging of MHI-148 in lung-cancer nude mice model. Ex vivo imaging was also been measured by testing the major tissue fluorescence intensity. And, the small molecular compound MHI-148 had low cytotoxicity which could be visualized at 1 h post-injection in tumor. From ex vivo fluorescence imaging, the tumor showed the highest uptake of MHI-148 among all the selected organs expect for the time point of 2 h. MHI-148 could be used for effective imaging in lung cancer tissue with good stability and specificity, which suggested that MHI-148 could be an effective tumor clinical imaging agent.

MHI-148是一种可以穿透肺癌细胞质膜的七甲胺花菁染料。在这里，我们测试了MHI-148在肺癌裸鼠模型中的细胞毒性体内成像。还通过测试主要组织的荧光强度来测量离体成像。并且，小分子化合物MHI-148具有低细胞毒性，这可以在肿瘤注射后1小时看到。根据离体荧光成像，在所有选定的器官中，在2 h的时间点内，肿瘤显示出最高的MHI-148摄取。MHI-148具有良好的稳定性和特异性，可用于肺癌组织的有效显像，提示MHI-148可作为一种有效的肿瘤临床显像剂。