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Nucleosome positioning and chromatin organization.
Current Opinion in Structural Biology ( IF 6.8 ) Pub Date : 2020-07-27 , DOI: 10.1016/j.sbi.2020.06.021
Jyotsana J Parmar 1 , Ranjith Padinhateeri 1
Affiliation  

In our cells, DNA is folded and packed with the help of many proteins into chromatin whose basic unit is a nucleosome-DNA wrapped around octamer of histone proteins. The chain of nucleosomes is further folded and arranged into many layers and has a dynamic organization. How does the complex chromatin organization emerge from interactions among DNA, histones, and non-histone proteins have been a question of great interest. Here we review recent literature that investigated how nucleosome positioning and nucleosome-mediated interactions drive chromatin organization. Unlike our earlier understanding, chromatin is organized into 3D domains of various sizes having irregularly organized nucleosomes. These domains emerge due to heterogeneous nucleosome positioning and diverse inter-nucleosome interactions that vary in space and time.

中文翻译:

核小体定位和染色质组织。

在我们的细胞中,DNA 在许多蛋白质的帮助下被折叠并堆积成染色质,染色质的基本单位是包裹在组蛋白八聚体周围的核小体 DNA。核小体链进一步折叠排列成许多层,并具有动态组织。DNA、组蛋白和非组蛋白之间的相互作用如何形成复杂的染色质组织一直是一个非常有趣的问题。在这里,我们回顾了最近研究核小体定位和核小体介导的相互作用如何驱动染色质组织的文献。与我们之前的理解不同,染色质被组织成各种大小的 3D 域,具有不规则组织的核小体。这些域的出现是由于异质核小体定位和不同的核小体间相互作用在空间和时间上不同。
更新日期:2020-07-27
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