The serine/arginine-rich splicing factors (SRs) belong to the serine arginine-rich protein family, which plays an extremely important role in the splicing process of precursor RNA. The SRs recognize the splicing elements on precursor RNA, then recruit and assemble spliceosome to promote or inhibit the occurrence of splicing events. In tumors, aberrant expression of SRs causes abnormal splicing of RNA, contributing to proliferation, migration and apoptosis resistance of tumor cells. Here, we reviewed the vital role of SRs in various tumors and discussed the promise of analyzing mRNA alternative splicing events in tumor. Further, we highlight the challenges and discussed the perspectives for the identification of new potential targets for cancer therapy via SRs family members.

中文翻译：

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富含丝氨酸/精氨酸的剪接因子：连接选择性剪接和癌症的桥梁。

富含丝氨酸/精氨酸的剪接因子(SRs)属于富含丝氨酸-精氨酸的蛋白家族，在前体RNA的剪接过程中发挥着极其重要的作用。SR识别前体RNA上的剪接元件，然后招募并组装剪接体以促进或抑制剪接事件的发生。在肿瘤中，SRs的异常表达会导致RNA剪接异常，从而促进肿瘤细胞的增殖、迁移和凋亡抵抗。在这里，我们回顾了 SR 在各种肿瘤中的重要作用，并讨论了分析肿瘤中 mRNA 选择性剪接事件的前景。此外，我们强调了挑战，并讨论了通过 SR 家族成员识别癌症治疗新潜在靶点的前景。