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The Roles of Noncardiomyocytes in Cardiac Remodeling.
International Journal of Biological Sciences ( IF 9.2 ) Pub Date : 2020-07-02 , DOI: 10.7150/ijbs.47180
Dan Yang 1, 2, 3 , Han-Qing Liu 4 , Fang-Yuan Liu 1, 2, 3 , Nan Tang 1, 2, 3 , Zhen Guo 1, 2, 3 , Shu-Qing Ma 1, 2, 3 , Peng An 1, 2, 3 , Ming-Yu Wang 1, 2, 3 , Hai-Ming Wu 1, 2, 3 , Zheng Yang 1, 2, 3 , Di Fan 1, 2, 3 , Qi-Zhu Tang 1, 2, 3
Affiliation  

Cardiac remodeling is a common characteristic of almost all forms of heart disease, including cardiac infarction, valvular diseases, hypertension, arrhythmia, dilated cardiomyopathy and other conditions. It is not merely a simple outcome induced by an increase in the workload of cardiomyocytes (CMs). The remodeling process is accompanied by abnormalities of cardiac structure as well as disturbance of cardiac function, and emerging evidence suggests that a wide range of cells in the heart participate in the initiation and development of cardiac remodeling. Other than CMs, there are numerous noncardiomyocytes (non-CMs) that regulate the process of cardiac remodeling, such as cardiac fibroblasts and immune cells (including macrophages, lymphocytes, neutrophils, and mast cells). In this review, we summarize recent knowledge regarding the definition and significant effects of various non-CMs in the pathogenesis of cardiac remodeling, with a particular emphasis on the involved signaling mechanisms. In addition, we discuss the properties of non-CMs, which serve as targets of many cardiovascular drugs that reduce adverse cardiac remodeling.

中文翻译:

非心肌细胞在心脏重塑中的作用。

心脏重塑是几乎所有形式的心脏病的共同特征,包括心肌梗塞、瓣膜疾病、高血压、心律失常、扩张型心肌病和其他病症。这不仅仅是心肌细胞(CM)工作量增加引起的简单结果。重构过程伴随着心脏结构的异常以及心功能的紊乱,新的证据表明心脏中的多种细胞参与了心脏重构的启动和发展。除了CM之外,还有大量的非心肌细胞(non-CM)调节心脏重塑过程,例如心脏成纤维细胞和免疫细胞(包括巨噬细胞、淋巴细胞、中性粒细胞和肥大细胞)。在这篇综述中,我们总结了有关各种非 CM 的定义和在心脏重塑发病机制中的显着影响的最新知识,特别强调了所涉及的信号传导机制。此外,我们还讨论了非 CM 的特性,它们是许多减少不良心脏重塑的心血管药物的靶标。
更新日期:2020-07-02
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