[Zn(dima)(H₂O)_0.5]·H₂O (1), a three-dimensional metal organic framework (MOF) with high porosity was formed by self-assembly of 4,6-di(1 h-imidazol-1-yl)isophthalic acid (H₂dima) and Zn²⁺ ion. Owning to its excellent luminescence and excellent water stability, complex 1 can be used as a super sensitive sensor to detect Fe³⁺ ions via the behaviors of fluorescence quenching. At the same time, the mechanism for the fluorescence quenching is also further discussed. Furthermore, the prevention effect of the compound on the deep vein thrombosis of the lower extremities (DVT) after lower venous CHIVA surgery was evaluated in vivo. Firstly, the DVT animal models was constructed and the number of platelets was measured with flow cytometry and content of clotting factor IX and anticoagulant factor III was also detected with Lowry method after compound treatment. The molecular docking simulation results indicate that the Zn(II) complex has activity to protein docking pocket with different sizes.

中文翻译：

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一种新的 Zn(II) 配合物：水中 Fe3+ 离子的荧光检测和通过调节血小板数量和凝血因子活性对 DVT 的预防作用。

[Zn(dima)(H ₂ O) _0.5 ]·H ₂ O ( 1 ), 4,6-di(1 h-imidazol) 自组装形成高孔隙率三维金属有机骨架 (MOF) -1-基)间苯二甲酸(H ₂ dima)和Zn ²⁺离子。由于其优异的发光性和优异的水稳定性，络合物1可用作超灵敏传感器，通过荧光猝灭行为检测Fe ^3+离子。同时，还进一步探讨了荧光猝灭的机理。此外，评估了该化合物对下肢 CHIVA 手术后下肢深静脉血栓形成 (DVT) 的预防作用体内。首先，构建DVT动物模型，复方治疗后采用流式细胞术检测血小板数量，采用Lowry法检测凝血因子IX和抗凝因子III的含量。分子对接模拟结果表明Zn(II)配合物对不同大小的蛋白质对接袋均具有活性。