Objective . Touch and proprioception are essential to motor function as shown by the movement deficits that result from the loss of these senses, e.g. due to neuropathy of sensory nerves. To achieve a high-performance brain-controlled prosthetic arm/hand thus requires the restoration of somatosensation, perhaps through intracortical microstimulation (ICMS) of somatosensory cortex (S1). The challenge is to generate patterns of neuronal activation that evoke interpretable percepts. We present a framework to design optimal spatiotemporal patterns of ICMS (STIM) that evoke naturalistic patterns of neuronal activity and demonstrate performance superior to four previous approaches. Approach . We recorded multiunit activity from S1 during a center-out reach task (from proprioceptive neurons in Brodmann’s area 2) and during application of skin indentations (from cutaneous neurons in Brodmann’s area 1). We implemented a computational model of a cortical hypercolumn and used a ...

中文翻译：

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一个基于模型的综合框架，用于优化设计假肢感觉电刺激仿生模式。

客观的 。触觉和本体感觉对于运动功能至关重要，如由于这些感觉丧失（例如由于感觉神经的神经病变）导致的运动缺陷所表明的。因此，为了实现高性能的大脑控制的假肢手臂/手，需要恢复体感，也许可以通过体感皮层（S1）的皮层内微刺激（ICMS）来恢复。挑战在于生成能唤起可解释感知的神经元激活模式。我们提出了一个设计最佳 ICMS (STIM) 时空模式的框架，该框架能够唤起神经元活动的自然模式，并证明其性能优于之前的四种方法。方法 。我们在中心向外触及任务（来自布罗德曼区域 2 的本体感觉神经元）和应用皮肤压痕期间（来自布罗德曼区域 1 的皮肤神经元）记录了 S1 的多单元活动。我们实现了皮质超柱的计算模型并使用了......