Implantable neuroelectronic interfaces have enabled breakthrough advances in the clinical diagnosis and treatment of neurological disorders, as well as in fundamental studies of brain function, behavior, and disease. Intracranial electroencephalography (EEG) mapping with stereo-EEG (sEEG) depth electrodes is routinely adopted for precise epilepsy diagnostics and surgical treatment, while deep brain stimulation has become the standard of care for managing movement disorders. Intracortical microelectrode arrays for high-fidelity recordings of neural spiking activity have led to impressive demonstrations of the power of brain-machine interfaces for motor and sensory functional recovery. Yet, despite the rapid pace of technology development, the issue of establishing a safe, long-term, stable, and functional interface between neuroelectronic devices and the host brain tissue still remains largely unresolved. A body of work spanning at least the last 15 years suggests that safe, chro...

中文翻译：

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凝胶、喷射器、蚊子和磁铁：软神经探针植入策略的回顾。

植入式神经电子接口使神经系统疾病的临床诊断和治疗以及脑功能、行为和疾病的基础研究取得了突破性进展。使用立体脑电图 (sEEG) 深度电极进行颅内脑电图 (EEG) 测绘通常用于精确的癫痫诊断和手术治疗，而深部脑刺激已成为治疗运动障碍的标准治疗方法。用于高保真记录神经尖峰活动的皮质内微电极阵列已经令人印象深刻地展示了脑机接口在运动和感觉功能恢复方面的力量。然而，尽管技术发展迅速，但在神经电子设备和宿主脑组织之间建立安全、长期、稳定和功能性接口的问题仍然很大程度上尚未解决。至少过去 15 年的大量工作表明，安全、环保...