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Deficits in auditory predictive coding in individuals with the psychosis risk syndrome: Prediction of conversion to psychosis.
Journal of Psychopathology and Clinical Science ( IF 4.6 ) Pub Date : 2020-08-01 , DOI: 10.1037/abn0000513 Susanna L Fryer 1 , Brian J Roach 1 , Holly K Hamilton 1 , Peter Bachman 2 , Aysenil Belger 3 , Ricardo E Carrión 4 , Erica Duncan 5 , Jason Johannesen 6 , Gregory A Light 7 , Margaret Niznikiewicz 8 , Jean Addington 9 , Carrie E Bearden 10 , Kristin S Cadenhead 7 , Tyrone D Cannon 11 , Barbara A Cornblatt 4 , Thomas H McGlashan 6 , Diana O Perkins 3 , Larry Seidman 8 , Ming Tsuang 7 , Elaine F Walker 12 , Scott W Woods 6 , Daniel H Mathalon 1
Journal of Psychopathology and Clinical Science ( IF 4.6 ) Pub Date : 2020-08-01 , DOI: 10.1037/abn0000513 Susanna L Fryer 1 , Brian J Roach 1 , Holly K Hamilton 1 , Peter Bachman 2 , Aysenil Belger 3 , Ricardo E Carrión 4 , Erica Duncan 5 , Jason Johannesen 6 , Gregory A Light 7 , Margaret Niznikiewicz 8 , Jean Addington 9 , Carrie E Bearden 10 , Kristin S Cadenhead 7 , Tyrone D Cannon 11 , Barbara A Cornblatt 4 , Thomas H McGlashan 6 , Diana O Perkins 3 , Larry Seidman 8 , Ming Tsuang 7 , Elaine F Walker 12 , Scott W Woods 6 , Daniel H Mathalon 1
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The mismatch negativity (MMN) event-related potential (ERP) component is increasingly viewed as a prediction error signal elicited when a deviant sound violates the prediction that a frequent "standard" sound will repeat. Support for this predictive coding framework emerged with the identification of the repetition positivity (RP), a standard stimulus ERP component that increases with standard repetition and is thought to reflect strengthening of the standard's memory trace and associated predictive code. Using electroencephalographic recordings, we examined the RP elicited by repeating standard tones presented during a traditional "constant standard" MMN paradigm in individuals with the psychosis risk syndrome (PRS; n = 579) and healthy controls (HC; n = 241). Clinical follow-up assessments identified PRS participants who converted to a psychotic disorder (n = 77) and PRS nonconverters who were followed for the entire 24-month clinical follow-up period and either remained symptomatic (n = 144) or remitted from the PRS (n = 94). In HC, RP linearly increased from early- to late-appearing standards within local trains of repeating standards (p < .0001), consistent with auditory predictive code/memory trace strengthening. Relative to HC, PRS participants showed a reduced RP across standards (p = .0056). PRS converters showed a relatively small RP deficit for early appearing standards relative to HC (p = .0.0107) and a more prominent deficit for late-appearing standards (p = .0006) relative to both HC and PRS-remitted groups. Moreover, greater RP deficits predicted shorter time to conversion in a subsample of unmedicated PRS individuals (p = .02). Thus, auditory predictive coding/memory trace deficits precede psychosis onset and predict future psychosis risk in PRS individuals. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
中文翻译:
精神病风险综合征患者的听觉预测编码缺陷:转换为精神病的预测。
失配负性 (MMN) 事件相关电位 (ERP) 组件越来越多地被视为当异常声音违反频繁“标准”声音将重复的预测时引发的预测误差信号。对这种预测编码框架的支持随着重复阳性 (RP) 的识别而出现,RP 是一种标准刺激 ERP 组件,随着标准重复而增加,并被认为反映了标准记忆轨迹和相关预测代码的加强。使用脑电图记录,我们检查了在精神病风险综合征(PRS;n = 579)和健康对照(HC;n = 241)的个体中,在传统的“恒定标准”MMN 范式中重复出现的标准音调引起的 RP。临床随访评估确定了转变为精神病的 PRS 参与者 (n = 77) 和在整个 24 个月临床随访期间被随访且仍有症状 (n = 144) 或从 PRS 中缓解的 PRS 未转变者(n = 94)。在 HC 中,RP 在重复标准的本地系列中从早到晚出现标准线性增加 (p < .0001),与听觉预测代码/记忆痕迹强化一致。相对于 HC,PRS 参与者显示出跨标准的 RP 降低 (p = .0056)。PRS 转换器显示出相对于 HC 较早出现的标准的 RP 赤字相对较小 (p = .0.0107),而相对于 HC 和 PRS 缓解组而言,较晚出现的标准 (p = .0006) 的RP 赤字更为突出。而且,在未接受药物治疗的 PRS 个体的子样本中,更大的 RP 缺陷预测更短的转换时间(p = .02)。因此,听觉预测编码/记忆痕迹缺陷先于精神病发作并预测 PRS 个体未来的精神病风险。(PsycInfo 数据库记录 (c) 2020 APA,保留所有权利)。
更新日期:2020-08-01
中文翻译:
精神病风险综合征患者的听觉预测编码缺陷:转换为精神病的预测。
失配负性 (MMN) 事件相关电位 (ERP) 组件越来越多地被视为当异常声音违反频繁“标准”声音将重复的预测时引发的预测误差信号。对这种预测编码框架的支持随着重复阳性 (RP) 的识别而出现,RP 是一种标准刺激 ERP 组件,随着标准重复而增加,并被认为反映了标准记忆轨迹和相关预测代码的加强。使用脑电图记录,我们检查了在精神病风险综合征(PRS;n = 579)和健康对照(HC;n = 241)的个体中,在传统的“恒定标准”MMN 范式中重复出现的标准音调引起的 RP。临床随访评估确定了转变为精神病的 PRS 参与者 (n = 77) 和在整个 24 个月临床随访期间被随访且仍有症状 (n = 144) 或从 PRS 中缓解的 PRS 未转变者(n = 94)。在 HC 中,RP 在重复标准的本地系列中从早到晚出现标准线性增加 (p < .0001),与听觉预测代码/记忆痕迹强化一致。相对于 HC,PRS 参与者显示出跨标准的 RP 降低 (p = .0056)。PRS 转换器显示出相对于 HC 较早出现的标准的 RP 赤字相对较小 (p = .0.0107),而相对于 HC 和 PRS 缓解组而言,较晚出现的标准 (p = .0006) 的RP 赤字更为突出。而且,在未接受药物治疗的 PRS 个体的子样本中,更大的 RP 缺陷预测更短的转换时间(p = .02)。因此,听觉预测编码/记忆痕迹缺陷先于精神病发作并预测 PRS 个体未来的精神病风险。(PsycInfo 数据库记录 (c) 2020 APA,保留所有权利)。