To design, develop and study a novel drug delivery system for intraocular applications. The spin coating technique was applied to develop a polymeric, drug-eluting thin film consisting of a blend of organic polymers [poly (D, L lactide coglycolide) lactide: glycolide 75: 25, PLGA and polycaprolactone, PCL] and dexamethasone on the surface of intraocular lenses (IOLs). The initial durability of the IOLs during spinning was assessed. Information about the structural and optical properties of the modified IOLs was extracted using atomic force microscopy, scanning electron microscopy and spectroscopic ellipsometry. A drug release study was conducted for 8 weeks. The IOLs were durable in spinning speeds higher than the ones used to develop thin films. Single-layer thin films were successfully developed on the optics and the haptics of the lenses. The films formed nanopores with encapsulated aggregates of dexamethasone. The spectroscopic ellipsometry showed an acceptable optical transparency of the lenses regardless of the deposition of the drug-eluting films on their surface. The drug release study demonstrated gradual dexamethasone release over the selected period. In conclusion, the novel drug-eluting IOL system exhibited desired properties regarding its transparency and drug release rate. Further research is necessary to assess their suitability as an intraocular drug delivery system.

中文翻译：

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人工晶状体表面聚合物、药物洗脱单层薄膜的设计、表征和药物释放研究。

设计、开发和研究一种用于眼内应用的新型药物输送系统。旋涂技术用于开发一种聚合物、药物洗脱薄膜，该薄膜由表面上的有机聚合物[聚（D，L丙交酯共乙交酯）丙交酯：乙交酯75：25，PLGA和聚己内酯，PCL]和地塞米松的混合物组成人工晶状体 (IOL)。评估了旋转过程中 IOL 的初始耐久性。使用原子力显微镜、扫描电子显微镜和光谱椭偏仪提取了有关改性 IOL 的结构和光学特性的信息。进行了为期 8 周的药物释放研究。IOL 在旋转速度上比用于开发薄膜的旋转速度更耐用。在镜片的光学和触觉上成功开发了单层薄膜。这些薄膜形成了具有封装的地塞米松聚集体的纳米孔。无论药物洗脱膜在其表面上的沉积情况如何，光谱椭偏仪均显示出可接受的镜片光学透明度。药物释放研究表明地塞米松在选定时期内逐渐释放。总之，新型药物洗脱 IOL 系统在透明度和药物释放率方面表现出理想的特性。需要进一步的研究来评估它们作为眼内给药系统的适用性。药物释放研究表明地塞米松在选定时期内逐渐释放。总之，新型药物洗脱 IOL 系统在透明度和药物释放率方面表现出理想的特性。需要进一步的研究来评估它们作为眼内给药系统的适用性。药物释放研究表明地塞米松在选定时期内逐渐释放。总之，新型药物洗脱 IOL 系统在透明度和药物释放率方面表现出理想的特性。需要进一步的研究来评估它们作为眼内给药系统的适用性。