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Resting-State Functional Magnetic Resonance Imaging Connectivity Between Semantic and Phonological Regions of Interest May Inform Language Targets in Aphasia
Journal of Speech Language and Hearing Research Pub Date : 2020-08-05 , DOI: 10.1044/2020_jslhr-19-00117 Amy E Ramage 1 , Semra Aytur 2 , Kirrie J Ballard 3
Purpose Brain imaging has provided puzzle pieces in the understanding of language. In neurologically healthy populations, the structure of certain brain regions is associated with particular language functions (e.g., semantics, phonology). In studies on focal brain damage, certain brain regions or connections are considered sufficient or necessary for a given language function. However, few of these account for the effects of lesioned tissue on the “functional” dynamics of the brain for language processing. Here, functional connectivity (FC) among semantic–phonological regions of interest (ROIs) is assessed to fill a gap in our understanding about the neural substrates of impaired language and whether connectivity strength can predict language performance on a clinical tool in individuals with aphasia. Method Clinical assessment of language, using the Western Aphasia Battery–Revised, and resting-state functional magnetic resonance imaging data were obtained for 30 individuals with chronic aphasia secondary to left-hemisphere stroke and 18 age-matched healthy controls. FC between bilateral ROIs was contrasted by group and used to predict Western Aphasia Battery–Revised scores. Results Network coherence was observed in healthy controls and participants with stroke. The left–right premotor cortex connection was stronger in healthy controls, as reported by New et al. (2015) in the same data set. FC of (a) connections between temporal regions, in the left hemisphere and bilaterally, predicted lexical–semantic processing for auditory comprehension and (b) ipsilateral connections between temporal and frontal regions in both hemispheres predicted access to semantic–phonological representations and processing for verbal production. Conclusions Network connectivity of brain regions associated with semantic–phonological processing is predictive of language performance in poststroke aphasia. The most predictive connections involved right-hemisphere ROIs—particularly those for which structural adaptions are known to associate with recovered word retrieval performance. Predictions may be made, based on these findings, about which connections have potential as targets for neuroplastic functional changes with intervention in aphasia. Supplemental Material https://doi.org/10.23641/asha.12735785
中文翻译:
静息态功能磁共振成像感兴趣的语义和语音区域之间的连通性可以为失语症的语言目标提供信息
目的 大脑成像为理解语言提供了拼图。在神经健康人群中,某些大脑区域的结构与特定的语言功能(例如语义、语音)相关。在局灶性脑损伤的研究中,某些大脑区域或连接被认为对于特定的语言功能是充分或必要的。然而,这些研究很少解释受损组织对大脑语言处理“功能”动态的影响。在这里,对语义-语音感兴趣区域(ROI)之间的功能连接(FC)进行评估,以填补我们对语言障碍的神经基质以及连接强度是否可以预测失语症个体在临床工具上的语言表现的理解空白。 方法 使用西方失语症电池修订版进行语言临床评估,并获得了 30 名继发于左半球中风的慢性失语症患者和 18 名年龄匹配的健康对照者的静息态功能磁共振成像数据。双侧 ROI 之间的 FC 按组进行对比,并用于预测西方失语症电池修订评分。 结果 在健康对照和中风参与者中观察到网络一致性。New 等人报道,健康对照组的左右前运动皮层连接更强。(2015)在同一数据集中。(a)左半球和双侧颞区之间的连接,预测听觉理解的词汇-语义处理;(b)两个半球颞区和额叶区之间的同侧连接,预测语义-语音表征和语言处理的访问生产。 结论 与语义语音处理相关的大脑区域的网络连接可以预测中风后失语症的语言表现。最具预测性的连接涉及右半球的 ROI,尤其是那些已知结构适应与恢复的单词检索性能相关的连接。根据这些发现,可以预测哪些连接有可能成为失语症干预中神经可塑性功能变化的目标。 补充材料 https://doi.org/10.23641/asha.12735785
更新日期:2020-08-05
Journal of Speech Language and Hearing Research Pub Date : 2020-08-05 , DOI: 10.1044/2020_jslhr-19-00117 Amy E Ramage 1 , Semra Aytur 2 , Kirrie J Ballard 3
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中文翻译:
静息态功能磁共振成像感兴趣的语义和语音区域之间的连通性可以为失语症的语言目标提供信息