Asymmetric dimethylarginine and L-homoarginine prospectively relate to carotid wall thickness in a South African cohort.,Amino Acids

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Asymmetric dimethylarginine and L-homoarginine prospectively relate to carotid wall thickness in a South African cohort.
Amino Acids ( IF 3.5 ) Pub Date : 2020-06-29 , DOI: 10.1007/s00726-020-02866-9
Maserame C Mokhaneli ₁ , Carla M T Fourie _{1,

2} , Shani Botha-Le Roux _{1,

2} , Rainer H Böger _{3,

4} , Edzard Schwedhelm _{3,

4} , Catharina M C Mels _{1,

2}

Affiliation

Background and aims

The l-arginine derivatives asymmetric (ADMA) and symmetric dimethylarginine (SDMA), as well as l-homoarginine may have opposing effects in the pathogenesis of atherosclerosis. We aimed to investigate (i) 5-year changes in arginine derivatives, and (ii) the association between baseline arginine derivatives and follow-up measures of carotid wall thickness in South Africans.

Methods and results

This study included men (n = 187) and women (n = 396) who took part in the 2010 and 2015 data collections of the South African arm of the Prospective Urban and Rural Epidemiology (PURE) study. Arginine derivatives were determined in plasma with liquid chromatography-tandem mass spectrometry. Carotid intima-media thickness (cIMT) and cross-sectional wall area (CSWA) were determined with B-mode ultrasonography.

Results

Mean values of arginine derivatives did not change over time. In the study group, follow-up cIMT (β = − 0.10 p = 0.018) and CSWA (β = − 0.12; p = 0.004) inversely associated with baseline l-homoarginine, and cIMT inversely associated with ADMA (β = − 0.09; p = 0.033). In women, CSWA inversely associated with both ADMA (β = − 0.11; p = 0.034) and l-homoarginine (β = − 0.11; p = 0.024). No such associations were found in men.

Conclusion

These results suggest that higher levels of l-homoarginine may play a protective role against vascular injury and delay progression of carotid wall thickening in this cohort. The role of ADMA in atherosclerosis deserves further investigation in this population.

中文翻译：

不对称的二甲基精氨酸和L-高精氨酸可能与南非队列中的颈动脉壁厚度有关。

背景和目标

的升精氨酸衍生物不对称（ADMA）和对称二甲基精氨酸（SDMA），以及升高精氨酸可以具有相对的动脉粥样硬化的发病机制的影响。我们旨在调查（i）精氨酸衍生物的5年变化，以及（ii）基线精氨酸衍生物与南非颈动脉壁厚度随访措施之间的关联。

方法与结果

这项研究包括男性（n = 187）和女性（n = 396），他们参加了前瞻性城市和农村流行病学研究（PURE）的南非分部2010年和2015年的数据收集。用液相色谱-串联质谱法测定血浆中的精氨酸衍生物。用B型超声检查确定颈动脉内膜中层厚度（cIMT）和横截面积（CSWA）。

结果

精氨酸衍生物的平均值不随时间变化。在研究组中，随访结果cIMT（β = − 0.10 p = 0.018）和CSWA（β = − 0.12; p = 0.004）与基线1-高精氨酸成反比，而cIMT与ADMA成反比（β = − 0.09; p = 0.033）。在女性中，CSWA与ADMA（β = − 0.11; p = 0.034）和1-高精氨酸（β = − 0.11; p = 0.024）均呈负相关。在男性中未发现此类关联。