Abstract ATP-Binding Cassette (ABC) transporters are involved in cholesterol metabolism and their dysfunctions could lead to obesity-associated complications. It was investigated whether SNPs in the ABCA1 (rs1800977 and rs2230806), ABCA7 (rs2279796) and ABCG1 (rs692383 and rs3827225) genes can modulate the responsiveness of 137 obese women to a weight-loss dietary intervention. Thus, anthropometric and lipid profiles were collected at baseline and after nine weeks of a calorie-restricted diet of 600kcal per day and participants were genotyped for the ABC genes SNPs. Regarding the transversal analysis, the ABCA7 rs2279796 GG genotype was associated with higher levels of total cholesterol and LDL-c at baseline (p = 0.044 for both). Association between ABCG1 rs692383 AA genotype and lower BMI were found in the post-diet moment, however, statistical significance was lost after multi-test correction. Regarding the longitudinal analysis, after multi-test correction, the association remained between ABCG1 rs692383 G allele and HDL-c levels: G allele carriers had a lower HDL-c reduction (p = 0.043). Results suggest the standard weight-loss diet applied in this study could attenuate the ABCA7 rs2279796 GG genotype effects found at baseline and non-dyslipidemic obese women with ABCG1 rs692383 G allele are benefitting from the diet with a lower reduction in HDL-c levels.

中文翻译：

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ABC 转运蛋白基因变异是否可能影响肥胖女性的减肥饮食结果？

摘要 ATP 结合盒 (ABC) 转运蛋白参与胆固醇代谢，其功能障碍可能导致肥胖相关并发症。研究人员调查了 ABCA1（rs1800977 和 rs2230806）、ABCA7（rs2279796）和 ABCG1（rs692383 和 rs3827225）基因中的 S​​NP 是否可以调节 137 名肥胖女性对减肥饮食干预的反应。因此，在基线和每天 600kcal 热量限制饮食九周后收集人体测量和血脂概况，并对参与者进行 ABC 基因 SNP 基因分型。关于横向分析，ABCA7 rs2279796 GG 基因型与基线时较高水平的总胆固醇和 LDL-c 相关（两者的 p = 0.044）。ABCG1 rs692383 AA 基因型与较低 BMI 之间的关联在节食后被发现，但经过多重检验校正后，统计学意义消失。关于纵向分析，经过多重测试校正，ABCG1 rs692383 G等位基因和HDL-c水平之间的关联仍然存在：G等位基因携带者的HDL-c降低较低（p = 0.043）。结果表明，本研究中采用的标准减肥饮食可以减弱基线时发现的 ABCA7 rs2279796 GG 基因型效应，并且携带 ABCG1 rs692383 G 等位基因的非血脂异常肥胖女性受益于 HDL-c 水平降低幅度较小的饮食。