Following release of short periods of unilateral ureteral obstruction (UUO), glomerular filtration rate (GFR) recovers by time. However, research in experimental animal models, has demonstrated the presence of ongoing element of renal interstitial fibrosis few weeks following UUO reversal. Interstitial fibrosis can cause deterioration in GFR and it is not known if it leads to an ongoing slow deterioration in other renal functions despite the apparent initial recovery post-reversal. To investigate this, rats underwent a 72-hour reversible UUO. Renal functions of the non-obstructed (NOK) and previously obstructed (POK) kidneys were measured one month, 4 months and 18 months post-reversal. GFR in the POK and NOK was similar up to 18 months post-reversal. However, there was an ongoing tubulointerstitial fibrosis and the degree of tubular atrophy and dilatation deteriorated by time. This was associated with an increase in urinary albumin leakage and alterations in renal injury markers, pro-inflammatory and pro-fibrotic cytokines and in p53, from 4 months onward despite the recovery in GFR. In conclusion, several aspects of renal functions continue to deteriorate following reversal of relatively short periods of UUO despite the initial recovery in GFR. This might stimulate further research in this area and might have clinical implications in terms of determining the best time for intervention following acute ureteral obstruction and long-term monitoring of these individuals.

中文翻译：

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尽管GFR最初有所恢复，但短期单侧输尿管梗阻后长期肾功能恶化。

短期释放单侧输尿管梗阻（UUO）后，肾小球滤过率（GFR）随时间恢复。然而，在实验动物模型中的研究表明，UUO逆转后数周，肾间质纤维化仍在进行。间质纤维化可导致GFR恶化，尽管逆转后明显恢复，但尚不清楚是否会导致其他肾功能的持续缓慢恶化。为了对此进行研究，大鼠经历了72小时的可逆UUO。在逆转后1个月，4个月和18个月测量未阻塞（NOK）和先前阻塞（POK）肾脏的肾功能。POK和NOK的GFR在逆转后的18个月内相似。然而，有持续的肾小管间质纤维化，肾小管萎缩和扩张程度随时间而恶化。尽管GFR恢复，但从4个月起，这与尿白蛋白渗漏增加，肾脏损伤标志物，促炎和促纤维化细胞因子以及p53的改变有关。总之，尽管肾小球滤过率（GFR）最初有所恢复，但相对短时间的UUO逆转后，肾功能的某些方面继续恶化。这可能会刺激该领域的进一步研究，并可能在确定急性输尿管梗阻和对这些个体进行长期监测后确定最佳干预时间方面具有临床意义。尽管GFR恢复，但从4个月开始，促炎性和促纤维化细胞因子以及p53中的促炎性和促纤维化细胞因子。总之，尽管肾小球滤过率（GFR）最初有所恢复，但相对短时间的UUO逆转后，肾功能的某些方面继续恶化。这可能会刺激该领域的进一步研究，并可能在确定急性输尿管梗阻和对这些个体进行长期监测后确定最佳干预时间方面具有临床意义。尽管GFR恢复，但从4个月开始，促炎性和促纤维化细胞因子以及p53中的促炎性和促纤维化细胞因子。总之，尽管肾小球滤过率（GFR）最初有所恢复，但相对短时间的UUO逆转后，肾功能的某些方面继续恶化。这可能会刺激该领域的进一步研究，并可能在确定急性输尿管梗阻和对这些个体进行长期监测后确定最佳干预时间方面具有临床意义。