Cholesterol is an essential component of mammalian membranes, and its homeostasis is strictly regulated, with imbalances causing atherosclerosis, Niemann Pick disease, and familial hypercholesterolemia. Cellular cholesterol supply is mediated by LDL-cholesterol import and de novo cholesterol biosynthesis, and both pathways are adjusted to cellular demand by the cholesterol-sensitive SREBP2 transcription factor. Cholesterol homeostasis is modulated by a wide variety of metabolic pathways and the ubiquitination machinery, in particular E3 ubiquitin ligases. In this article, we review recent progress in understanding the role of E3 ubiquitin ligases in the metabolic control of cellular sterol homeostasis.

中文翻译：

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泛素介导的固醇稳态调节。

胆固醇是哺乳动物细胞膜的重要组成部分，胆固醇的稳态受到严格调节，失衡会导致动脉粥样硬化，尼曼·皮克病和家族性高胆固醇血症。LDL-胆固醇的导入和从头胆固醇的生物合成介导了细胞中胆固醇的供应，胆固醇敏感的SREBP2转录因子调节了两种途径以适应细胞需求。胆固醇的稳态受多种代谢途径和泛素化机制，特别是E3泛素连接酶的调节。在本文中，我们回顾了了解E3泛素连接酶在细胞固醇稳态代谢控制中的作用的最新进展。