Background: Naringenin (NRG) has many health benefits, including; anti-atherogenic, antiinflammatory, antitumor, and anticancer activity, as well as improvement of lipid metabolism. However, its use is limited due to its low solubility and bioavailability.

Objectives: The aim of the present patent study was the preparation and optimization of NRG loaded Novel Lipid Nanocapsules (LNCs) for the improvement of NRG solubility and gut permeability.

中文翻译：

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脂质纳米胶囊提高柚皮素在大鼠小肠非外翻囊中的溶解度和渗透性

背景：柚皮素 (NRG) 具有许多健康益处，包括；抗动脉粥样硬化、抗炎、抗肿瘤和抗癌活性，以及​​改善脂质代谢。然而，由于其溶解度和生物利用度低，其使用受到限制。

目的：本专利研究的目的是制备和优化负载 NRG 的新型脂质纳米胶囊 (LNC)，以提高 NRG 溶解度和肠道通透性。