Applied Physiology, Nutrition, and Metabolism, Volume 45, Issue 8, Page 845-850, August 2020.
The aim of the present study was to test the hypothesis that inflammation mediates the associations among food intake, clinical-nutritional status, and plasma homocysteine (Hcys) in hemodialysis (HD) subjects. This was a cross-sectional analysis of data on 129 subjects undergoing HD (58.9% male, 61.8 ± 15.5 years of age) from the cohort Nutrition and Genetics on HD outcomes (NUGE-HD study). Sociodemographic, anthropometric, and metabolic data were collected, and food intake was assessed using a quantitative food frequency questionnaire. Plasma C-reactive protein (CRP) was used as an inflammatory marker. Data were analyzed by structural equation modeling. Regarding the direct effects, complex B vitamin intake was negatively associated with body mass index, and diabetes mellitus was positively associated with CRP. Plasma CRP also showed a negative association with Hcys, and the ratio of saturated and polyunsaturated fatty acids intake showed a positive association with Hcys. Regarding indirect effects, the results showed that the relationship between the presence of diabetes mellitus and Hcys is mediated by plasma CRP. In conclusion, the ratio of saturated and polyunsaturated fatty acids had a direct effect on plasma Hcys, whereas inflammation had a direct and mediating effect on the relationship between Hcys and diabetes mellitus in HD subjects. Novelty In end-stage renal disease, CRP influences plasma Hcys directly and also indirectly through its mediating effect. The quantity and quality of dietary fatty acids influence plasma Hcys concentrations in HD subjects.

中文翻译：

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血液透析受试者的饮食摄入量，临床营养状况和同型半胱氨酸：炎症的中介作用（NUGE-HD研究）。

应用生理学，营养与代谢》，第45卷，第8期，第845-850页，2020年8月。
本研究的目的是检验在血液透析（HD）受试者中炎症介导食物摄入，临床营养状况和血浆同型半胱氨酸（Hcys）之间关联的假设。这是对来自HD结局的营养和遗传学队列研究（NUGE-HD研究）的129名HD患者的数据的横断面分析（男性58.9％，61.8±15.5岁）。收集社会人口统计学，人体测量学和代谢数据，并使用定量食物频率问卷评估食物摄入量。血浆C反应蛋白（CRP）被用作炎症标记。通过结构方程模型分析数据。在直接影响方面，复杂的维生素B摄入量与体重指数呈负相关，而糖尿病与CRP呈正相关。血浆CRP也与Hcys呈负相关，饱和和多不饱和脂肪酸摄入量的比例与Hcys呈正相关。关于间接作用，结果表明，血浆CRP介导了糖尿病的存在与Hcys之间的关系。总之，饱和脂肪酸和多不饱和脂肪酸的比例对血浆Hcys具有直接影响，而炎症对HD受试者中Hcys与糖尿病之间的关系具有直接和中介作用。新颖性在终末期肾脏疾病中，CRP直接或间接通过其介导作用影响血浆Hcys。膳食脂肪酸的数量和质量会影响HD受试者的血浆Hcys浓度。饱和脂肪酸和多不饱和脂肪酸的摄入比例与Hcys呈正相关。关于间接作用，结果表明，血浆CRP介导了糖尿病的存在与Hcys之间的关系。总之，饱和脂肪酸和多不饱和脂肪酸的比例对血浆Hcys具有直接影响，而炎症对HD受试者中Hcys与糖尿病之间的关系具有直接和中介作用。新颖性在终末期肾脏疾病中，CRP直接或间接通过其介导作用影响血浆Hcys。膳食脂肪酸的数量和质量会影响HD受试者的血浆Hcys浓度。饱和脂肪酸和多不饱和脂肪酸的摄入比例与Hcys呈正相关。关于间接作用，结果表明，血浆CRP介导了糖尿病的存在与Hcys之间的关系。总之，饱和脂肪酸和多不饱和脂肪酸的比例对血浆Hcys具有直接影响，而炎症对HD受试者中Hcys与糖尿病之间的关系具有直接和中介作用。新颖性在终末期肾脏疾病中，CRP直接或间接通过其介导作用影响血浆Hcys。膳食脂肪酸的数量和质量会影响HD受试者的血浆Hcys浓度。结果表明，血浆CRP介导了糖尿病的存在与Hcys之间的关系。总之，饱和脂肪酸和多不饱和脂肪酸的比例对血浆Hcys具有直接影响，而炎症对HD受试者中Hcys与糖尿病之间的关系具有直接和中介作用。新颖性在终末期肾脏疾病中，CRP直接或间接通过其介导作用影响血浆Hcys。膳食脂肪酸的数量和质量会影响HD受试者的血浆Hcys浓度。结果表明，血浆CRP介导了糖尿病的存在与Hcys之间的关系。总之，饱和脂肪酸和多不饱和脂肪酸的比例对血浆Hcys具有直接影响，而炎症对HD受试者中Hcys与糖尿病之间的关系具有直接和中介作用。新颖性在终末期肾脏疾病中，CRP直接或间接通过其介导作用影响血浆Hcys。膳食脂肪酸的数量和质量会影响HD受试者的血浆Hcys浓度。新颖性在终末期肾脏疾病中，CRP直接或间接通过其介导作用影响血浆Hcys。膳食脂肪酸的数量和质量会影响HD受试者的血浆Hcys浓度。新颖性在终末期肾脏疾病中，CRP直接或间接通过其介导作用影响血浆Hcys。膳食脂肪酸的数量和质量会影响HD受试者的血浆Hcys浓度。